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Inhibitor Report for: ARUK3005518

General
Type Fragment inhibitor of Notum, Indole
Chemical_Nomenclature (3~{a}~{S})-2,2-bis(fluoranyl)-3~{a},4-dihydro-3~{H}-pyrrolo[1,2-a]indol-1-one
Canonical SMILES c1ccc2c(c1)C[C@@H]3N2C(=O)C(C3)(F)F [C]1=[C][C]=C2C(=[C]1)N3[C](C2)CC(C3=O)(F)F
InChI InChI=1S/C11H9F2NO/c12-11(13)6-8-5-7-3-1-2-4-9(7)14(8)10(11)15/h1-4,8H,5-6H2/t8-/m0/s1
InChIKey FBNLACZWDFCRLD-QMMMGPOBSA-N
Other name(s) RGO ; Compound 5m
________________________________________________________________________________________________
MW|209.19
Formula|C11H9F2NO
CAS_number|
PubChem|
UniChem|FBNLACZWDFCRLD-QMMMGPOBSA-N
IUPHAR|
Wikipedia|

Target
Families | ARUK3005518 ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 8BT0: Structure of the human Wnt deacylase Notum in complex with ARUK3005518
Protein | human-NOTUM

References:
Search PubMed for references concerning: ARUK3005518
    Title: Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity
    Atkinson BN, Willis NJ, Zhao Y, Patel C, Frew S, Costelloe K, Magno L, Svensson F, Jones EY, Fish PV
    Ref: Eur Journal of Medicinal Chemistry, 251:115132, 2023 : PubMed