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Inhibitor Report for: Ac-Phe-OH

Acetylphenylalanine is a hazardous amphipathic metabolite of phenylalanine. It appears in large amount in urine of patients with phenylketonuria due to the lack of phenylalanine hydroxylase


General
Type Product-like inhibitor, Peptide
Chemical_Nomenclature (2S)-2-acetamido-3-phenylpropanoic acid
Canonical SMILES CC(=O)NC(CC1=CC=CC=C1)C(=O)O
InChI InChI=1S/C11H13NO3/c1-8(13)12-10(11(14)15)7-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
InChIKey CBQJSKKFNMDLON-JTQLQIEISA-N
Other name(s) N-Acetyl-L-phenylalanine ; Acetyl-L-phenylalanine ; Acetylphenylalanine ; L-N-Acetylphenylalanine
________________________________________________________________________________________________
MW|207.22
Formula|C11H13NO3
CAS_number|2018-61-3
PubChem|74839
UniChem|CBQJSKKFNMDLON-JTQLQIEISA-N
IUPHAR|
Wikipedia|

Target
Families | Ac-Phe-OH ligand of proteins in family: ACPH_Peptidase_S9
Stucture | 1 structure: 2HU7: Acylaminoacyl peptidase (ApAAP) Ac-Phe-OH complex
Protein | aerpe-APE1547

References:
Search PubMed for references concerning: Ac-Phe-OH
    Title: The acylaminoacyl peptidase from Aeropyrum pernix K1 thought to be an exopeptidase displays endopeptidase activity
    Kiss AL, Hornung B, Radi K, Gengeliczki Z, Sztaray B, Juhasz T, Szeltner Z, Harmat V, Polgar L
    Ref: Journal of Molecular Biology, 368:509, 2007 : PubMed

            

    Title: Crystallization and preliminary crystallographic analysis of porcine acylaminoacyl peptidase
    Wright H, Kiss AL, Szeltner Z, Polgar L, Fulop V
    Ref: Acta Crystallographica Sect F Struct Biol Cryst Commun, 61:942, 2005 : PubMed