Acotiamide
Acotiamide is a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AChE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms
General
Type : Drug,Sulfur Compound,Carboxamide
Chemical_Nomenclature : N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide
Canonical SMILES : CC(C)N(CCNC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2O)OC)OC)C(C)C
InChI : InChI=1S\/C21H30N4O5S\/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26\/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27)
InChIKey : TWHZNAUBXFZMCA-UHFFFAOYSA-N
Other name(s) : UNII-D42OWK5383,CHEBI:34523,MZ-338,AC1NQZWJ
MW : 450.55
Formula : C21H30N4O5S
CAS_number : 185106-16-5
PubChem : 5282338
UniChem : TWHZNAUBXFZMCA-UHFFFAOYSA-N
IUPHAR :
Wikipedia : Acotiamide
Target
References (13)
| Title : Acotiamide Hydrochloride, a Therapeutic Agent for Functional Dyspepsia, Enhances Acetylcholine-induced Contraction via Inhibition of Acetylcholinesterase Activity in Circular Muscle Strips of Guinea Pig Stomach - Ito_2016_Drug.Res.(Stuttg)_66_196 |
| Author(s) : Ito K , Kawachi M , Matsunaga Y , Hori Y , Ozaki T , Nagahama K , Hirayama M , Kawabata Y , Shiraishi Y , Takei M , Tanaka T |
| Ref : Drug Res (Stuttg) , 66 :196 , 2016 |
| Abstract : Ito_2016_Drug.Res.(Stuttg)_66_196 |
| ESTHER : Ito_2016_Drug.Res.(Stuttg)_66_196 |
| PubMedSearch : Ito_2016_Drug.Res.(Stuttg)_66_196 |
| PubMedID: 26418413 |
| Title : Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide, A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, in Rat Stomach - Yoshii_2016_Pharm.Res_33_292 |
| Author(s) : Yoshii K , Iikura M , Hirayama M , Toda R , Kawabata Y |
| Ref : Pharm Res , 33 :292 , 2016 |
| Abstract : Yoshii_2016_Pharm.Res_33_292 |
| ESTHER : Yoshii_2016_Pharm.Res_33_292 |
| PubMedSearch : Yoshii_2016_Pharm.Res_33_292 |
| PubMedID: 26350104 |
| Title : Distribution of acotiamide, an orally active acetylcholinesterase inhibitor, into the myenteric plexus of rat and dog stomachs - Yoshii_2016_Life.Sci_145_93 |
| Author(s) : Yoshii K , Yamaguchi T , Hirayama M , Toda R , Kinomoto T , Kawabata Y , Chiba K |
| Ref : Life Sciences , 145 :93 , 2016 |
| Abstract : Yoshii_2016_Life.Sci_145_93 |
| ESTHER : Yoshii_2016_Life.Sci_145_93 |
| PubMedSearch : Yoshii_2016_Life.Sci_145_93 |
| PubMedID: 26682939 |
| Title : Emerging treatments in neurogastroenterology: Acotiamade, a novel treatment option for functional dyspepsia - Matsushita_2016_Neurogastroenterol.Motil_28_631 |
| Author(s) : Matsushita M , Masaoka T , Suzuki H |
| Ref : Neurogastroenterol Motil , 28 :631 , 2016 |
| Abstract : Matsushita_2016_Neurogastroenterol.Motil_28_631 |
| ESTHER : Matsushita_2016_Neurogastroenterol.Motil_28_631 |
| PubMedSearch : Matsushita_2016_Neurogastroenterol.Motil_28_631 |
| PubMedID: 26730749 |
| Title : Effect of acotiamide on gastric emptying in healthy adult humans - Zai_2014_Eur.J.Clin.Invest_44_1215 |
| Author(s) : Zai H , Matsueda K , Kusano M , Urita Y , Saito Y , Kato H |
| Ref : European Journal of Clinical Investigation , 44 :1215 , 2014 |
| Abstract : Zai_2014_Eur.J.Clin.Invest_44_1215 |
| ESTHER : Zai_2014_Eur.J.Clin.Invest_44_1215 |
| PubMedSearch : Zai_2014_Eur.J.Clin.Invest_44_1215 |
| PubMedID: 25370953 |
| Title : Efficacy of acotiamide in combination with esomeprazole for functional dyspepsia refractory to proton-pump inhibitor monotherapy - Mayanagi_2014_Tohoku.J.Exp.Med_234_237 |
| Author(s) : Mayanagi S , Kishino M , Kitagawa Y , Sunamura M |
| Ref : Tohoku J Exp Med , 234 :237 , 2014 |
| Abstract : Mayanagi_2014_Tohoku.J.Exp.Med_234_237 |
| ESTHER : Mayanagi_2014_Tohoku.J.Exp.Med_234_237 |
| PubMedSearch : Mayanagi_2014_Tohoku.J.Exp.Med_234_237 |
| PubMedID: 25382232 |
| Title : Acotiamide: first global approval - Nolan_2013_Drugs_73_1377 |
| Author(s) : Nolan ML , Scott LJ |
| Ref : Drugs , 73 :1377 , 2013 |
| Abstract : Nolan_2013_Drugs_73_1377 |
| ESTHER : Nolan_2013_Drugs_73_1377 |
| PubMedSearch : Nolan_2013_Drugs_73_1377 |
| PubMedID: 23881665 |
| Title : A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia - Matsueda_2012_Gut_61_821 |
| Author(s) : Matsueda K , Hongo M , Tack J , Saito Y , Kato H |
| Ref : Gut , 61 :821 , 2012 |
| Abstract : Matsueda_2012_Gut_61_821 |
| ESTHER : Matsueda_2012_Gut_61_821 |
| PubMedSearch : Matsueda_2012_Gut_61_821 |
| PubMedID: 22157329 |
| Title : Acotiamide, a new orally active acetylcholinesterase inhibitor, stimulates gastrointestinal motor activity in conscious dogs - Nagahama_2012_Neurogastroenterol.Motil_24_566 |
| Author(s) : Nagahama K , Matsunaga Y , Kawachi M , Ito K , Tanaka T , Hori Y , Oka H , Takei M |
| Ref : Neurogastroenterol Motil , 24 :566 , 2012 |
| Abstract : Nagahama_2012_Neurogastroenterol.Motil_24_566 |
| ESTHER : Nagahama_2012_Neurogastroenterol.Motil_24_566 |
| PubMedSearch : Nagahama_2012_Neurogastroenterol.Motil_24_566 |
| PubMedID: 22429221 |
| Title : Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats - Kawachi_2011_Eur.J.Pharmacol_666_218 |
| Author(s) : Kawachi M , Matsunaga Y , Tanaka T , Hori Y , Ito K , Nagahama K , Ozaki T , Inoue N , Toda R , Yoshii K , Hirayama M , Kawabata Y , Takei M |
| Ref : European Journal of Pharmacology , 666 :218 , 2011 |
| Abstract : Kawachi_2011_Eur.J.Pharmacol_666_218 |
| ESTHER : Kawachi_2011_Eur.J.Pharmacol_666_218 |
| PubMedSearch : Kawachi_2011_Eur.J.Pharmacol_666_218 |
| PubMedID: 21651906 |
| Title : Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach - Yoshii_2011_J.Pharm.Sci_100_4965 |
| Author(s) : Yoshii K , Hirayama M , Nakamura T , Toda R , Hasegawa J , Takei M , Mera Y , Kawabata Y |
| Ref : J Pharm Sci , 100 :4965 , 2011 |
| Abstract : Yoshii_2011_J.Pharm.Sci_100_4965 |
| ESTHER : Yoshii_2011_J.Pharm.Sci_100_4965 |
| PubMedSearch : Yoshii_2011_J.Pharm.Sci_100_4965 |
| PubMedID: 21630282 |
| Title : Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. is an optimal dosage - Matsueda_2010_Neurogastroenterol.Motil_22_618 |
| Author(s) : Matsueda K , Hongo M , Tack J , Aoki H , Saito Y , Kato H |
| Ref : Neurogastroenterol Motil , 22 :618 , 2010 |
| Abstract : Matsueda_2010_Neurogastroenterol.Motil_22_618 |
| ESTHER : Matsueda_2010_Neurogastroenterol.Motil_22_618 |
| PubMedSearch : Matsueda_2010_Neurogastroenterol.Motil_22_618 |
| PubMedID: 20059698 |
| Title : Acotiamide (Z-338) as a possible candidate for the treatment of functional dyspepsia - Suzuki_2010_Neurogastroenterol.Motil_22_595 |
| Author(s) : Suzuki H , Hibi T |
| Ref : Neurogastroenterol Motil , 22 :595 , 2010 |
| Abstract : Suzuki_2010_Neurogastroenterol.Motil_22_595 |
| ESTHER : Suzuki_2010_Neurogastroenterol.Motil_22_595 |
| PubMedSearch : Suzuki_2010_Neurogastroenterol.Motil_22_595 |
| PubMedID: 20553562 |