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Inhibitor Report for: Amodiaquine

Amodiaquine is an orally active 4-aminoquinoline used for the therapy of malaria effective against some chloroquine-resistant strains of Plasmodium falciparum It is likely able to inhibit heme polymerase. Amodiaquine has been linked to severe cases of acute hepatitis and used only as treatment and not for prophylaxis against malaria. Amodiaquine shows mixed competitive-non-competitive inhibition type of AChE and shows slow and partial reactivation of sarin-, cyclosarin- and VX-inhibited cholinesterases. However it failed to reactivate tabun-inhibited human cholinesterases


General
Type Quinoline, Not A/B H target, Drug
Chemical_Nomenclature 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol
Canonical SMILES CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O
InChI InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)
InChIKey OVCDSSHSILBFBN-UHFFFAOYSA-N
Other name(s) ADQ ; Amodiaquin ; Camoquine ; Flavoquine ; Camoquin ; Camochin
________________________________________________________________________________________________
MW|355.86
Formula|C20H22ClN3O
CAS_number|86-42-0
PubChem|2165
UniChem|OVCDSSHSILBFBN-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Amodiaquine ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: Amodiaquine
    Title: New therapeutic approaches and novel alternatives for organophosphate toxicity
    Katz FS, Pecic S, Schneider L, Zhu Z, Hastings A, Luzac M, MacDonald J, Landry DW, Stojanovic MN
    Ref: Toxicol Lett, 291:1, 2018 : PubMed

            

    Title: Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds
    Bierwisch A, Wille T, Thiermann H, Worek F
    Ref: Toxicol Lett, 246:49, 2016 : PubMed