Aroylacrylic-acid-amide-Tacrine-10
General
Type : Derivative of Tacrine,Alkyl linked bis-ligand
Chemical_Nomenclature : 4-(3,4-Dimethylphenyl)-4-oxo-N-phenyl-2-[8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl-amino]-butanamide
Canonical SMILES : C1=CC=C2C(=C1)C(=C3C(=N2)CCCC3)NCCCCCCCCNC(C(=O)NC4=CC=CC=C4)CC(=O)C5=CC=C(C(=C5)C)C
InChI : InChI=1S\/C39H48N4O2\/c1-28-22-23-30(26-29(28)2)37(44)27-36(39(45)42-31-16-8-7-9-17-31)40-24-14-5-3-4-6-15-25-41-38-32-18-10-12-20-34(32)43-35-21-13-11-19-33(35)38\/h7-10,12,16-18,20,22-23,26,36,40H,3-6,11,13-15,19,21,24-25,27H2,1-2H3,(H,41,43)(H,42,45)
InChIKey : KRHBZGPHDZSMQQ-UHFFFAOYSA-N
Other name(s) :
MW :
Formula : C39H48N4O2
CAS_number :
PubChem :
UniChem : KRHBZGPHDZSMQQ-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Aroylacrylic-acid-amide-Tacrine-10 ligand of proteins in family: ACHE || BCHE
Stucture :
Protein : human-BCHE || torca-ACHE
References (1)
| Title : The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents - Vitorovic-Todorovic_2019_Chem.Biol.Interact_13ChEPon_309_108714 |
| Author(s) : Vitorovic-Todorovic MD , Worek F , Perdih A , Bauk SD , Vujatovic TB , Cvijetic IN |
| Ref : Chemico-Biological Interactions , 309 :108714 , 2019 |
| Abstract : Vitorovic-Todorovic_2019_Chem.Biol.Interact_13ChEPon_309_108714 |
| ESTHER : Vitorovic-Todorovic_2019_Chem.Biol.Interact_13ChEPon_309_108714 |
| PubMedSearch : Vitorovic-Todorovic_2019_Chem.Biol.Interact_13ChEPon_309_108714 |
| PubMedID: 31228470 |