BAY
inhibitor of Hormone-sensitive_lipase_like
General
Type : Piperidine,Urea derivative
Chemical_Nomenclature : 3-methyl-2-[(3S)-3-methylpiperidine-1-carbonyl]-4-propan-2-yl-1,2-oxazol-5-one
Canonical SMILES : CC1CCCN(C1)C(=O)N2C(=C(C(=O)O2)C(C)C)C
InChI : InChI=1S\/C14H22N2O3\/c1-9(2)12-11(4)16(19-13(12)17)14(18)15-7-5-6-10(3)8-15\/h9-10H,5-8H2,1-4H3\/t10-\/m0\/s1
InChIKey : XWESKOHENXWEAX-JTQLQIEISA-N
Other name(s) : CHEMBL106126,BDBM50138735,(S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-carbonyl)isoxazol-5(2H)-one,4-Isopropyl-3-methyl-2-((S)-3-methyl-piperidine-1-carbonyl)-2H-isoxazol-5-one,MFCD26145167
MW : 266.33
Formula : C14H22N2O3
CAS_number :
PubChem : 10038557
UniChem : XWESKOHENXWEAX-JTQLQIEISA-N
IUPHAR :
Wikipedia :
Target
References (2)
| Title : Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose - Claus_2005_J.Pharmacol.Exp.Ther_315_1396 |
| Author(s) : Claus TH , Lowe DB , Liang Y , Salhanick AI , Lubeski CK , Yang L , Lemoine L , Zhu J , Clairmont KB |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 315 :1396 , 2005 |
| Abstract : Claus_2005_J.Pharmacol.Exp.Ther_315_1396 |
| ESTHER : Claus_2005_J.Pharmacol.Exp.Ther_315_1396 |
| PubMedSearch : Claus_2005_J.Pharmacol.Exp.Ther_315_1396 |
| PubMedID: 16162821 |
| Title : In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase - Lowe_2004_Bioorg.Med.Chem.Lett_14_3155 |
| Author(s) : Lowe DB , Magnuson S , Qi N , Campbell AM , Cook J , Hong Z , Wang M , Rodriguez M , Achebe F , Kluender H , Wong WC , Bullock WH , Salhanick AI , Witman-Jones T , Bowling ME , Keiper C , Clairmont KB |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :3155 , 2004 |
| Abstract : Lowe_2004_Bioorg.Med.Chem.Lett_14_3155 |
| ESTHER : Lowe_2004_Bioorg.Med.Chem.Lett_14_3155 |
| PubMedSearch : Lowe_2004_Bioorg.Med.Chem.Lett_14_3155 |
| PubMedID: 15149665 |