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Inhibitor Report for: BNPP

Inhibitor of carboxylesterases (and also AADAC), substrate of metallo-beta-lactamase


General
Type Organophosphate, pNP
Chemical_Nomenclature Bis(4-nitrophenyl)phosphate
Canonical SMILES C1=CC(=CC=C1[N+](=O)[O-])OP(=O)(O)OC2=CC=C(C=C2)[N+](=O)[O-]
InChI InChI=1S/C12H9N2O8P/c15-13(16)9-1-5-11(6-2-9)21-23(19,20)22-12-7-3-10(4-8-12)14(17)18/h1-8H,(H,19,20)
InChIKey MHSVUSZEHNVFKW-UHFFFAOYSA-N
Other name(s) Bis(4-nitrophenyl)phosphate ; Bis(4-nitrophenyl) phosphate ; Bis(4-nitrophenyl) hydrogen phosphate ; Bis(p-nitrophenyl)phosphate ; bis-(p-nitrophenyl)phosphoric acid
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MW|340.18
Formula|C12H9N2O8P
CAS_number|645-15-8
PubChem|255
UniChem|MHSVUSZEHNVFKW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Bis_(p-nitrophenyl)phosphate

Target
Families | BNPP ligand of proteins in family: Carb_B_Chordata, Arylacetamide_deacetylase

References:
Search PubMed for references concerning: BNPP

5 more
    Title: Optimal pH 8.5 to 9 for the Hydrolysis of Vixotrigine and Other Basic Substrates of Carboxylesterase-1 in Human Liver Microsomes
    Johnson JL, Huang J, Rooney M, Gu C
    Ref: Xenobiotica, :1, 2021 : PubMed

            

    Title: Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors
    Tsurkan LG, Hatfield MJ, Edwards CC, Hyatt JL, Potter PM
    Ref: Chemico-Biological Interactions, 203:226, 2013 : PubMed

            

    Title: Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor
    Eng H, Niosi M, McDonald TS, Wolford A, Chen Y, Simila ST, Bauman JN, Warmus J, Kalgutkar AS
    Ref: Xenobiotica, 40:369, 2010 : PubMed