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Inhibitor Report for: Benzil

prototype of carboxylesterase inhibitors not inhibitor of Cholinesterases


General
Type Aromatic dione
Chemical_Nomenclature 1,2-diphenylethane-1,2-dione
Canonical SMILES C1=CC=C(C=C1)C(=O)C(=O)C2=CC=CC=C2
InChI InChI=1S/C14H10O2/c15-13(11-7-3-1-4-8-11)14(16)12-9-5-2-6-10-12/h1-10H
InChIKey WURBFLDFSFBTLW-UHFFFAOYSA-N
Other name(s) Diphenylethanedione ; Dibenzoyl ; Diphenylglyoxal ; Bibenzoyl ; diphenyl-Ethanedione ; 1,2-Diphenylethanedione
________________________________________________________________________________________________
MW|210.23
Formula|C14H10O2
CAS_number|134-81-6
PubChem|8651
UniChem|WURBFLDFSFBTLW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Benzil

Target
Families | Benzil ligand of proteins in family: Carboxylesterase, Carb_B_Chordata
Stucture | 1 structure: 1YAJ: Crystal Structure of Human Liver Carboxylesterase in complex with benzil
Protein | human-CES1

References:
Search PubMed for references concerning: Benzil

1 more
    Title: Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors
    Tsurkan LG, Hatfield MJ, Edwards CC, Hyatt JL, Potter PM
    Ref: Chemico-Biological Interactions, 203:226, 2013 : PubMed

            

    Title: Mammalian carboxylesterases: from drug targets to protein therapeutics
    Redinbo MR, Potter PM
    Ref: Drug Discov Today, 10:313, 2005 : PubMed

            

    Title: Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases
    Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K and Potter PM <2 more author(s)>
    Ref: Journal of Medicinal Chemistry, 48:2906, 2005 : PubMed