Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Benzil

prototype of carboxylesterase inhibitors not inhibitor of Cholinesterases


General
Type Aromatic dione
Chemical_Nomenclature 1,2-diphenylethane-1,2-dione
Canonical SMILES C1=CC=C(C=C1)C(=O)C(=O)C2=CC=CC=C2
InChI InChI=1S/C14H10O2/c15-13(11-7-3-1-4-8-11)14(16)12-9-5-2-6-10-12/h1-10H
InChIKey WURBFLDFSFBTLW-UHFFFAOYSA-N
Other name(s) Diphenylethanedione ; Dibenzoyl ; Diphenylglyoxal ; Bibenzoyl ; diphenylethane-1,2-dione ; diphenyl-Ethanedione ; 1,2-Diphenylethanedione
________________________________________________________________________________________________
MW|210.23
Formula|C14H10O2
CAS_number|134-81-6
PubChem|8651
UniChem|WURBFLDFSFBTLW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Benzil

Target
Families | Benzil ligand of proteins in family: Carboxylesterase, Carb_B_Chordata
Stucture | 1 structure: 1YAJ: Crystal Structure of Human Liver Carboxylesterase in complex with benzil
Protein | human-CES1

References:
Search PubMed for references concerning: Benzil

4 more
    Title: Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity
    Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM
    Ref: Mol Cancer Ther, 5:2281, 2006 : PubMed

            

    Title: Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety
    Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK and Potter PM <1 more author(s)>
    Ref: Journal of Medicinal Chemistry, 48:5543, 2005 : PubMed

            

    Title: Mammalian carboxylesterases: from drug targets to protein therapeutics
    Redinbo MR, Potter PM
    Ref: Drug Discov Today, 10:313, 2005 : PubMed