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Inhibitor Report for: Bis-galanthamine

bis-ligand used to increase AChE inhibition here the compound 6c is represented 10 methylenes linker . The most potent compound described


General
Type Derivative of Galanthamine, Alkaloid, Alkyl linked bis-ligand, Benzazepin
Chemical_Nomenclature 6H-benzofuro[3a,3,2-ef][2]benzazepinium, 4a,5,9,10-tetrahydro-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-4a,5,9,10-tetrahydro-6-hydroxy-3-methoxy-6H-benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-, bromide, (6R,8aS)- (1:1)
Canonical SMILES COC1=C2C3=C(CN(CCC34C=CC(CC4O2)O)CCCCCCCCCC[N+]5=CC6=C7C(=C(C=C6)OC)OC8C7(CC5)C=CC(C8)O)C=C1.[Br-]
InChI InChI=1S/C42H55N2O6.BrH/c1-47-33-13-11-29-27-43(23-19-41-17-15-31(45)25-35(41)49-39(33)37(29)41)21-9-7-5-3-4-6-8-10-22-44-24-20-42-18-16-32(46)26-36(42)50-40-34(48-2)14-12-30(28-44)38(40)42;/h11-18,27,31-32,35-36,45-46H,3-10,19-26,28H2,1-2H3;1H/q+1;/p-1/t31-,32-,35?,36-,41-,42-;/m0./s1
InChIKey QAMUMNIFAYGMCP-PQXBOIAPSA-M
Other name(s) CHEMBL415545 ; (6R,8aS)-6-Hydroxy-11-{10-[(4aS,6R,8aS)-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl}-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]b enzazepin-11-ium bromide
________________________________________________________________________________________________
MW|763.81
Formula|C42H56N2O6 Br
CAS_number|
PubChem|44372540
UniChem|QAMUMNIFAYGMCP-PQXBOIAPSA-M
IUPHAR|
Wikipedia|

Target
Families | Bis-galanthamine ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: Bis-galanthamine
    Title: Galanthamine as bis-functional ligand for the acetylcholinesterase
    Luttmann E, Linnemann E, Fels G
    Ref: J Mol Model (Online), 8:208, 2002 : PubMed

            

    Title: Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts
    Guillou C, Mary A, Renko DZ, Gras E, Thal C
    Ref: Bioorganic & Medicinal Chemistry Lett, 10:637, 2000 : PubMed