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Inhibitor Report for: CHEMBL1086968

General
Type Peptide, Thiazolidine, Cyclopropyl, Sulfur Compound
Chemical_Nomenclature [(2S,3aS,7aS)-2-(1,3-thiazolidine-3-carbonyl)-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-[(1R,2R)-2-phenylcyclopropyl]methanone
Canonical SMILES C1CCC2C(C1)CC(N2C(=O)C3CC3C4=CC=CC=C4)C(=O)N5CCSC5
InChI InChI=1S/C22H28N2O2S/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23/h1-3,6-7,16-20H,4-5,8-14H2/t16-,17-,18+,19-,20-/m0/s1
InChIKey NXSXRIHXEQSYEZ-KNJMJIDISA-N
Other name(s) S 17092 ; S-17092 ; SCHEMBL194654 ; GTPL6565 ; ZINC3825778
________________________________________________________________________________________________
MW|384.53
Formula|C22H28N2O2S
CAS_number|176797-26-5
PubChem|9929984
UniChem|NXSXRIHXEQSYEZ-KNJMJIDISA-N
IUPHAR|6565
Wikipedia|

Target
Families | CHEMBL1086968 ligand of proteins in family: S9N_PPCE_Peptidase_S9
Protein | human-PREP

References:
Search PubMed for references concerning: CHEMBL1086968

2 more
    Title: Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors
    Lawandi J, Gerber-Lemaire S, Juillerat-Jeanneret L, Moitessier N
    Ref: Journal of Medicinal Chemistry, 53:3423, 2010 : PubMed

            

    Title: S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies
    Morain P, Lestage P, De Nanteuil G, Jochemsen R, Robin JL, Guez D, Boyer PA
    Ref: CNS Drug Rev, 8:31, 2002 : PubMed

            

    Title: Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys
    Schneider JS, Giardiniere M, Morain P
    Ref: Neuropsychopharmacology, 26:176, 2002 : PubMed