Search PubMed for references concerning: CHEMBL3125346
Title: Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase Muscia GC, Hautmann S, Buldain GY, Asis SE, Gutschow M Ref: Bioorganic & Medicinal Chemistry Lett, 24:1545, 2014 : PubMed
A series of 2-(substituted) phenyl and 2-indolyl quinoline derivatives (10a-l) was synthesized by an efficient microwave-assisted, trifluoroacetic acid-catalyzed, solvent-free method. Evaluation of the inhibitory activity led to the identification of two quinoline inhibitors of cholesterol esterase. 2-(1H-Indol-3-yl)-6-nitro-4-phenylquinoline (10l; IC50=1.98muM) was characterized as a mixed-type inhibitor with a pronounced competitive binding mode.
