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Inhibitor Report for: Chlorpyrifos-oxon

Results from the metabolism in vivo of chlorpyrifos (oxygen replaces the sulfur atom)


General
Type Insecticide, Organophosphate
Chemical_Nomenclature diethyl (3,5,6-trichloropyridin-2-yl) phosphate
Canonical SMILES CCOP(=O)(OCC)OC1=NC(=C(C=C1Cl)Cl)Cl
InChI InChI=1S/C9H11Cl3NO4P/c1-3-15-18(14,16-4-2)17-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
InChIKey OTMOUPHCTWPNSL-UHFFFAOYSA-N
Other name(s) 3,5,6-trichloro-2-pyridyl diethyl phosphate ; 2,3,5-trichloro-6-diethoxyphosphoryloxy-pyridine ; Dursbanoxon ; Fospirate-ethyl ; Chlorpyrifos oxon ; Phospyrat ethyl ; Chloropyrifos oxon ; Dursban O-analog ; Dursban oxygen analog ; Chloropyrifos oxygen analog ; CCRIS 7774 ; chlorpyriphos oxon ; chlorpyryphos oxon ; chlorpyryfos oxon
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MW|334.52
Formula|C9H11Cl3NO4P
CAS_number|5598-15-2
PubChem|21804
UniChem|OTMOUPHCTWPNSL-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Chlorpyrifos-oxon ligand of proteins in family: ACHE
Stucture | 2 structures: 7P28, 7P89

References:
Search PubMed for references concerning: Chlorpyrifos-oxon

7 more
    Title: Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity
    Schopfer LM, Lockridge O
    Ref: Journal of Biological Chemistry, 293:13566, 2018 : PubMed

            

    Title: Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents
    Jiang W, Duysen EG, Hansen H, Shlyakhtenko L, Schopfer LM, Lockridge O
    Ref: Toxicol Sci, 115:183, 2010 : PubMed

            

    Title: Degradation by rat tissues in vitro of organophosphorus esters which inhibit cholinesterase
    Pla A, Johnson MK
    Ref: Biochemical Pharmacology, 38:1527, 1989 : PubMed