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Inhibitor Report for: Cisatracurium

Neuromuscular Nondepolarizing Agent, Nicotinic Antagonist, Neuromuscular blocking agent, (close to doxacurium) Cisatracurium is the 1R-cis 1'R-cis isomer of atracurium. Atracurium and Cisatracurium undergo spontaneous non-organ-dependent Hofmann degradation at physiological pH and temperature


General
Type Propionate, Isoquinoline, Neuromuscular Nondepolarizing Agents, Nicotinic antagonist, Bisquaternary, Not A/B H target
Chemical_Nomenclature 5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl
Canonical SMILES C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C
InChI InChI=1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2/t42-,43-,54-,55-/m1/s1
InChIKey YXSLJKQTIDHPOT-LJCJQEJUSA-N
Other name(s) cisatracurium besylate ; 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
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MW|929.14
Formula|C53H72N2O12
CAS_number|96946-42-8
PubChem|62887
UniChem|YXSLJKQTIDHPOT-LJCJQEJUSA-N
IUPHAR|
Wikipedia|Cisatracurium_besilate

Target

References:
Search PubMed for references concerning: Cisatracurium
    Title: Clinical pharmacokinetics of the newer neuromuscular blocking drugs
    Atherton DP, Hunter JM
    Ref: Clinical Pharmacokinetics, 36:169, 1999 : PubMed

            

    Title: [The clinical pharmacology of mivacurium]
    Diefenbach C, Mellinghoff H
    Ref: Anaesthesist, 46:385, 1997 : PubMed

            

    Title: [Esters and stereoisomers]
    Nigrovic V, Diefenbach C, Mellinghoff H
    Ref: Anaesthesist, 46:282, 1997 : PubMed