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Inhibitor Report for: Compound19n-quinolinol

IC50 AChE 161 nM


General
Type Trifluo, anti-Abeta-aggregation, Metal ion chelator, Quinoline, Multitarget, Derivative of Donepezil
Chemical_Nomenclature (E)-2-(2-(1-(2-(trifluoromethylbenzyl))-1,2,3,6-tetrahydropyridin-4-yl)vinyl)quinolin-8ol hydrochloride
Canonical SMILES C1=CC(=C2C(=C1)C=CC(=N2)C=CC3=CCN(CC3)CC4=C(C=CC=C4)C(F)(F)F)O
InChI InChI=1S/C24H21F3N2O/c25-24(26,27)21-6-2-1-4-19(21)16-29-14-12-17(13-15-29)8-10-20-11-9-18-5-3-7-22(30)23(18)28-20/h1-12,30H,13-16H2/b10-8+
InChIKey HCUMFCRMHUJZMD-CSKARUKUSA-N
Other name(s)
________________________________________________________________________________________________
MW|410.43
Formula|C24H21F3N2O
CAS_number|
PubChem|
UniChem|HCUMFCRMHUJZMD-CSKARUKUSA-N
IUPHAR|
Wikipedia|

Target
Families | Compound19n-quinolinol ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: Compound19n-quinolinol
    Title: Discovery of novel hybrids containing clioquinol-1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease
    Li X, Li T, Zhang P, Lu L, Sun Y, Zhang B, Allen S, White L, Phillips J and Xu J <2 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 244:114841, 2022 : PubMed