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Inhibitor Report for: Cpd8f-quinoline-carboxamide

LipY IC50 8.25 +/-0.43 microM (Orlistat <1.50). Highly selective towards the growth inhibition of hypoxic cultures of M. tuberculosis


General
Type Quinoline, Carboxamide
Chemical_Nomenclature 7-chloro-N-[(E)-(2,5-dimethoxyphenyl)methylideneamino]-6-fluoro-4-oxo-1H-quinoline-3-carboxamide
Canonical SMILES C1(=C(C=C2C(=C1)C(=C(C=N2)C(=O)NN=CC3=C(C=CC(=C3)OC)OC)O)Cl)F
InChI InChI=1S/C19H15ClFN3O4/c1-27-11-3-4-17(28-2)10(5-11)8-23-24-19(26)13-9-22-16-7-14(20)15(21)6-12(16)18(13)25/h3-9H,1-2H3,(H,22,25)(H,24,26)/b23-8+
InChIKey PDBWRWOZXDSIPK-LIMNOBDPSA-N
Other name(s)
________________________________________________________________________________________________
MW|403.79
Formula|C19H15ClFN3O4
CAS_number|
PubChem|72793819
UniChem|PDBWRWOZXDSIPK-LIMNOBDPSA-N
IUPHAR|
Wikipedia|

Target
Families | Cpd8f-quinoline-carboxamide ligand of proteins in family: Hormone-sensitive_lipase_like
Protein | myctu-Rv3097c

References:
Search PubMed for references concerning: Cpd8f-quinoline-carboxamide
    Title: Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia
    Saxena AK, Roy KK, Singh S, Vishnoi SP, Kumar A, Kashyap VK, Kremer L, Srivastava R, Srivastava BS
    Ref: Int J Antimicrob Agents, 42:27, 2013 : PubMed