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Inhibitor Report for: Cyclosarin

General
Type Chemical Warfare Agent, Organophosphate, Nerve Agent G-series, Derivative of Sarin
Chemical_Nomenclature [fluoro(methyl)phosphoryl]oxycyclohexane
Canonical SMILES CP(=O)(OC1CCCCC1)F
InChI InChI=1S/C7H14FO2P/c1-11(8,9)10-7-5-3-2-4-6-7/h7H,2-6H2,1H3
InChIKey SNTRKUOVAPUGAY-UHFFFAOYSA-N
Other name(s) GF ; Cyclohexyl sarin ; Cyclohexyl methylphosphonofluoridate ; Methyl cyclohexylfluorophosphonate ; Cyclosin ; CMPF ; Cyclohexylmethylphosphonofluoridate
________________________________________________________________________________________________
MW|180.16
Formula|C7H14FO2P
CAS_number|
PubChem|64505
UniChem|SNTRKUOVAPUGAY-UHFFFAOYSA-N
IUPHAR|
Wikipedia|Cyclosarin

Target
Families | Cyclosarin ligand of proteins in family: ACHE, BCHE, Carboxypeptidase_S10
Stucture | 4 structures (e.g. : 7BFV, 6WVP, 3ZLU... more)
Protein | mouse-ACHE, human-CTSA

References:
Search PubMed for references concerning: Cyclosarin

5 more
    Title: A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexyl methylphosphonofluoridate (GF agent) by in vitro and in vivo methods
    Kassa J, Cabal J
    Ref: Pharmacol Toxicol, 84:41, 1999 : PubMed

            

    Title: Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds
    Worek F, Widmann R, Knopff O, Szinicz L
    Ref: Archives of Toxicology, 72:237, 1998 : PubMed

            

    Title: Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases
    Worek F, Eyer P, Szinicz L
    Ref: Archives of Toxicology, 72:580, 1998 : PubMed