DA-12166
Evogliptin and DA-12228 are derivatives of DA-12166 DPP4 IC50 18.7 nM
General
Type : Gliptin,Trifluoro
Chemical_Nomenclature : (R)-4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)piperazin-2-one
Canonical SMILES : N[C@@H](CC(=O)N1CCNC(=O)C1)Cc1cc(F)c(F)cc1F
InChI : InChI=1S\/C14H16F3N3O2\/c15-10-6-12(17)11(16)4-8(10)3-9(18)5-14(22)20-2-1-19-13(21)7-20\/h4,6,9H,1-3,5,7,18H2,(H,19,21)\/t9-\/m1\/s1
InChIKey : SLQOQKROMQOJLJ-SECBINFHSA-N
Other name(s) : 8O3
MW : 315.29
Formula : C14H16F3N3O2
CAS_number :
PubChem : 137551959
UniChem : SLQOQKROMQOJLJ-SECBINFHSA-N
IUPHAR :
Wikipedia :
Target
Families : DA-12166 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture : 5Y7H Crystal structure of human DPP4 in complex with inhibitor DA-12166
Protein : human-DPP4
References (1)
| Title : Unique binding mode of Evogliptin with human dipeptidyl peptidase IV - Lee_2017_Biochem.Biophys.Res.Commun_494_452 |
| Author(s) : Lee HK , Kim MK , Kim HD , Kim HJ , Kim JW , Lee JO , Kim CW , Kim EE |
| Ref : Biochemical & Biophysical Research Communications , 494 :452 , 2017 |
| Abstract : Lee_2017_Biochem.Biophys.Res.Commun_494_452 |
| ESTHER : Lee_2017_Biochem.Biophys.Res.Commun_494_452 |
| PubMedSearch : Lee_2017_Biochem.Biophys.Res.Commun_494_452 |
| PubMedID: 29061303 |
| Gene_locus related to this paper: human-DPP4 |