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Inhibitor Report for: Diethyl-maleate

Not an inhibitor of alpha/beta hydrolases. Glutathione depleting agent. Used to test the involvment of glutathione-S-transferases in the resistance to insecticides. One of the key uses for the compound is in production of the pesticide Malathion


General
Type Synergist of insecticide, Not A/B H target
Chemical_Nomenclature diethyl (Z)-but-2-enedioate
Canonical SMILES CCOC(=O)C=CC(=O)OCC
InChI InChI=1S/C8H12O4/c1-3-11-7(9)5-6-8(10)12-4-2/h5-6H,3-4H2,1-2H3/b6-5-
InChIKey IEPRKVQEAMIZSS-WAYWQWQTSA-N
Other name(s) DEM ; Ethyl maleate ; Diethylmaleate ; Diethyl maleate ; Maleic acid, diethyl ester ; CHEBI:68508 ; CHEMBL2037000 ; ZINC100004207 ; SCHEMBL60423
________________________________________________________________________________________________
MW|172.18
Formula|C8H12O4
CAS_number|141-05-9
PubChem|5271566
UniChem|IEPRKVQEAMIZSS-WAYWQWQTSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: Diethyl-maleate

38 more
    Title: The overexpression of three cytochrome P450 genes CYP6CY14, CYP6CY22 and CYP6UN1 contributed to metabolic resistance to dinotefuran in melon/cotton aphid, Aphis gossypii Glover
    Chen A, Zhang H, Shan T, Shi X, Gao X
    Ref: Pestic Biochem Physiol, 167:104601, 2020 : PubMed

            

    Title: Synergism of organophosphorus insecticides by diethyl maleate and related compounds in house flies
    Welling W, de Vries JW
    Ref: Pesticide Biochemistry and Physiology, 23:358, 1985 : PubMed

            

    Title: Parathion and methyl parathion toxicity and metabolism in piperonyl butoxide and diethyl maleate pretreated mice
    Mirer FE, Levine BS, Murphy SD
    Ref: Chemico-Biological Interactions, 17:99, 1977 : PubMed