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Inhibitor Report for: Dihomo-gamma-linolenic-acid

Dihomo-gamma-linolenic acid (DGLA) is a precursor of physiologically active eicosanoids, including group 1 prostaglandins and thromboxanes. DGLA is used in combination with interferons for the enhancement of the anti-virus, anti-cancer, or anti-inflammatory effects, and in combination with prostaglandin E1 for the treatment of atopy of the skin and mucosa. For nutritional supplementation, also for treating dietary shortage or imbalance. The role of FASN inhibition is unknown. Dihomo-gamma-linolenic acid is a 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.


General
Type Fatty acid
Chemical_Nomenclature (8Z,11Z,14Z)-icosa-8,11,14-trienoic acid
Canonical SMILES CCCCCC=CCC=CCC=CCCCCCCC(=O)O
InChI InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
InChIKey HOBAELRKJCKHQD-QNEBEIHSSA-N
Other name(s) Dihomo-gamma-linolenic acid ; DGLA ; Gamma-Homolinolenic acid ; Homo-gamma-linolenic acid ; 8,11,14-Eicosatrienoic acid ; Cis-8,11,14-Eicosatrienoic Acid
________________________________________________________________________________________________
MW|306.48
Formula|C20H34O2
CAS_number|1783-84-2
PubChem|5280581
UniChem|HOBAELRKJCKHQD-QNEBEIHSSA-N
IUPHAR|
Wikipedia|

Target
Families | Dihomo-gamma-linolenic-acid ligand of proteins in family: Thioesterase
Protein | human-FASN

References:
Search PubMed for references concerning: Dihomo-gamma-linolenic-acid
    Title: Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid
    Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA
    Ref: Proc Natl Acad Sci U S A, 108:15757, 2011 : PubMed