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Inhibitor Report for: ERX-41

IT IS NOT AN INHIBITOR BUT A SPECIFIC LIGAND. Liu et al. published that targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress. They disclosed ERX-41 which specifically interacts with LIPA (human-LIPA)


General
Type oligobenzamide
Chemical_Nomenclature 4-[[4-[[3-(2-hydroxyethoxy)-4-nitrobenzoyl]amino]-3-(2-methylpropoxy)benzoyl]amino]-N-(4-methylcyclohexyl)-3-(2-methylpropoxy)benzamide
Canonical SMILES CC1CCC(CC1)NC(=O)C2=CC(=C(C=C2)NC(=O)C3=CC(=C(C=C3)NC(=O)C4=CC(=C(C=C4)[N+](=O)[O-])OCCO)OCC(C)C)OCC(C)C
InChI InChI=1S/C38H48N4O9/c1-23(2)21-50-33-18-26(36(44)39-29-11-6-25(5)7-12-29)8-13-30(33)40-37(45)27-9-14-31(34(19-27)51-22-24(3)4)41-38(46)28-10-15-32(42(47)48)35(20-28)49-17-16-43/h8-10,13-15,18-20,23-25,29,43H,6-7,11-12,16-17,21-22H2,1-5H3,(H,39,44)(H,40,45)(H,41,46)
InChIKey QOYORXKDWMJNHD-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|704.8
Formula|C38H48N4O9
CAS_number|
PubChem|153603617
UniChem|QOYORXKDWMJNHD-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | ERX-41 ligand of proteins in family: Acidic_Lipase
Protein | human-LIPA

References:
Search PubMed for references concerning: ERX-41
    Title: Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress
    Liu X, Viswanadhapalli S, Kumar S, Lee TK, Moore A, Ma S, Chen L, Hsieh M, Li M and Raj GV <19 more author(s)>
    Ref: Nat Cancer, :, 2022 : PubMed