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Inhibitor Report for: EZ120P

Modified version of Orlistat Tetrahydrolipstatin THL-alkyne EZ120 is selective for mycobacteria this is the alkyne of EZ120


General
Type Oxooxetan, Lipase inhibitor
Chemical_Nomenclature
Canonical SMILES C1(=CC=C(C=C1)N(C)C)C(NCCCCCC2OC(C2CCCCCCCC#C)=O)=O
InChI InChI=1S/C26H38N2O3/c1-4-5-6-7-8-9-11-14-23-24(31-26(23)30)15-12-10-13-20-27-25(29)21-16-18-22(19-17-21)28(2)3/h1,16-19,23-24H,5-15,20H2,2-3H3,(H,27,29)
InChIKey YFDWGEYULMRNNT-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|426.59
Formula|C26H38N2O3
CAS_number|
PubChem|
UniChem|YFDWGEYULMRNNT-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | EZ120P ligand of proteins in family: A85-Mycolyl-transferase
Protein | myctu-a85a, myctu-a85b, myctu-a85c

References:
Search PubMed for references concerning: EZ120P

2 more
    Title: Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling
    Li M, Patel HV, Cognetta AB, 3rd, Smith TC, 2nd, Mallick I, Cavalier JF, Previti ML, Canaan S, Aldridge BB and Seeliger JC <1 more author(s)>
    Ref: Cell Chemical Biology, 29:883, 2022 : PubMed

            

    Title: Cell Surface Biosynthesis and Remodeling Pathways in Mycobacteria Reveal New Drug Targets
    Shaku M, Ealand C, Kana BD
    Ref: Front Cell Infect Microbiol, 10:603382, 2020 : PubMed

            

    Title: An Antibacterial beta-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis
    Lehmann J, Cheng TY, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Sacchettini JC and Sieber SA <2 more author(s)>
    Ref: Angew Chem Int Ed Engl, 57:348, 2018 : PubMed