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Inhibitor Report for: Epicatechin-gallate

A natural product found in Parapiptadenia rigida. It has a role as a metabolite, an EC 3.2.1.1 (alpha-amylase) inhibitor and an EC 3.2.1.20 (alpha-glucosidase) inhibitor. One Hydroxy less than Epigallocatechin-gallate


General
Type Natural, Polyphenol, Benzoate
Chemical_Nomenclature [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Canonical SMILES C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
InChI InChI=1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2/t19-,21-/m1/s1
InChIKey LSHVYAFMTMFKBA-TZIWHRDSSA-N
Other name(s) (-)-Epicatechin gallate ; Epicatechin gallate ; (-)-Epicatechin-3-O-gallate ; (-)-epicatechingallate ; ECG ; CHEMBL36327 ; CHEBI:70255 ; SCHEMBL39047 ; ZINC3978503
________________________________________________________________________________________________
MW|442.4
Formula|C22H18O10
CAS_number|1257-08-5
PubChem|107905
UniChem|LSHVYAFMTMFKBA-TZIWHRDSSA-N
IUPHAR|
Wikipedia|

Target
Families | Epicatechin-gallate ligand of proteins in family: Arylacetamide_deacetylase
Protein | human-AADAC

References:
Search PubMed for references concerning: Epicatechin-gallate

3 more
    Title: Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase
    Yasuda K, Watanabe K, Fukami T, Nakashima S, Ikushiro SI, Nakajima M, Sakaki T
    Ref: Drug Metab Pharmacokinet, 39:100397, 2021 : PubMed

            

    Title: Fast identification of lipase inhibitors in oolong tea by using lipase functionalised Fe3O4 magnetic nanoparticles coupled with UPLC-MS/MS
    Zhu YT, Ren XY, Yuan L, Liu YM, Liang J, Liao X
    Ref: Food Chem, 173:521, 2015 : PubMed

            

    Title: (-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice
    Grove KA, Sae-tan S, Kennett MJ, Lambert JD
    Ref: Obesity (Silver Spring), 20:2311, 2012 : PubMed