Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: FL217

General
Type Multitarget, PPARgamma ligand, Cyclopropyl
Chemical_Nomenclature ~{N}-[[4-(cyclopropylsulfonylamino)-2-(trifluoromethyl)phenyl]methyl]-1-[(3-fluorophenyl)methyl]indole-5-carboxamide
Canonical SMILES c1cc(cc(c1)F)Cn2ccc3c2ccc(c3)C(=O)NCc4ccc(cc4C(F)(F)F)NS(=O)(=O)C5CC5
InChI InChI=1S/C27H23F4N3O3S/c28-21-3-1-2-17(12-21)16-34-11-10-18-13-19(5-9-25(18)34)26(35)32-15-20-4-6-22(14-24(20)27(29,30)31)33-38(36,37)23-7-8-23/h1-6,9-14,23,33H,7-8,15-16H2,(H,32,35)
InChIKey NONHTXRHOREFAH-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|545.55
Formula|C27H23F4N3O3S
CAS_number|
PubChem|
UniChem|NONHTXRHOREFAH-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | FL217 ligand of proteins in family: Epoxide_hydrolase
Stucture | 1 structure: 7P4K: Soluble epoxide hydrolase in complex with FL217
Protein | human-EPHX2

References:
Search PubMed for references concerning: FL217
    Title: Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor gamma Agonists/Soluble Epoxide Hydrolase Inhibitors
    Lillich FF, Willems S, Ni X, Kilu W, Borkowsky C, Brodsky M, Kramer JS, Brunst S, Hernandez-Olmos V and Proschak E <16 more author(s)>
    Ref: Journal of Medicinal Chemistry, :, 2021 : PubMed