Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: FP-Biotin

Serine Hydrolase probe consisting of a tag linked to a fluorophosphonate (FP) group, which specifically and covalently labels serines of enzymatically active serine hydrolases. ABPP-Probe (activity based protein profiling probe)



General
Type: Organophosphate, ABPP-Probe, Imidazole, Sulfur Compound, Biotin derivative
Chemical_Nomenclature: 10-[ethoxy(fluoro)phosphoryl]-N-[5-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]pentyl]decanamide
Canonical SMILES: CCOP(=O)(CCCCCCCCCC(=O)NCCCCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2)F
InChI: InChI=1S/C27H50FN4O5PS/c1-2-37-38(28,36)20-14-7-5-3-4-6-9-16-24(33)29-18-12-8-13-19-30-25(34)17-11-10-15-23-26-22(21-39-23)31-27(35)32-26/h22-23,26H,2-21H2,1H3,(H,29,33)(H,30,34)(H2,31,32,35)
InChIKey: ZIFSFLGSUTZFCP-UHFFFAOYSA-N
Other name(s): 10-Fluoroethoxyphosphinyl-N-biotinamidopentyldecanamide ; SCHEMBL13743155 ; CTK8E8183 ; RT-013047
MW: 592.75
Formula: C27H50FN4O5PS
CAS_number: 259270-28-5
PubChem: 24762158
IUPHAR:
Wikipedia:
No structure

References
Search PubMed for references concerning: FP-Biotin

16 more
    Title: Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine
    Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM
    Ref: Chemico-Biological Interactions, 180:492, 2009 : PubMed

            

    Title: Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin
    Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F and Lockridge O <4 more author(s)>
    Ref: Chemical Research in Toxicology, 21:1787, 2008 : PubMed

            

    Title: Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents
    Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 175:180, 2008 : PubMed