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Inhibitor Report for: FP-TAMRA

Tetramethylrhodamine fluorophosphonate. Serine Hydrolase probe consisting of a tag linked to a fluorophosphonate (FP) group, which specifically and covalently labels serines of enzymatically active serine hydrolases. ABPP-Probe (activity based protein profiling probe)



General
Type: Organophosphate, ABPP-Probe, Benzoate
Chemical_Nomenclature: 2-[3-(dimethylamino)-6-dimethylazaniumylidenexanthen-9-yl]-5-[10-[ethoxy(fluoro)phosphoryl]decylcarbamoyl]benzoate
Canonical SMILES: CCOP(=O)(CCCCCCCCCCNC(=O)C1=CC(=C(C=C1)C2=C3C=CC(=[N+](C)C)C=C3OC4=C2C=CC(=C4)N(C)C)C(=O)[O-])F
InChI: InChI=1S/C37H47FN3O6P/c1-6-46-48(38,45)22-14-12-10-8-7-9-11-13-21-39-36(42)26-15-18-29(32(23-26)37(43)44)35-30-19-16-27(40(2)3)24-33(30)47-34-25-28(41(4)5)17-20-31(34)35/h15-20,23-25H,6-14,21-22H2,1-5H3,(H-,39,42,43,44)
InChIKey: JEVJWIYMEMUCFU-UHFFFAOYSA-N
Other name(s): TAMRA-FP
MW: 679,76
Formula: C37H47FN3O6P
CAS_number:
PubChem: 139035304
IUPHAR:
Wikipedia:
No structure

References
Search PubMed for references concerning: FP-TAMRA
    Title: Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases
    Baggelaar MP, van Esbroeck AC, van Rooden EJ, Florea BI, Overkleeft HS, Marsicano G, Chaouloff F, van der Stelt M
    Ref: ACS Chemical Biology, 12:852, 2017 : PubMed

            

    Title: Biochemical and pharmacological characterization of human alpha/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)
    Navia-Paldanius D, Savinainen JR, Laitinen JT
    Ref: J Lipid Res, 53:2413, 2012 : PubMed