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Inhibitor Report for: Gallate

Tannins are natural polyphenolic compounds present in vascular plants. Hydrolyzable tannins are derivatives of gallic acid (3,4,5-trihydroxybenzoic acid) or its meta-depsidic forms that are esterified to polyol, catechin, or triterpenoid units. Gallate is product of hydrolysis of Ethyl-gallate. used in the pharmaceutical industry and is an important intermediate in the synthesis of the antibacterial agent trimethoprim


General
Type Benzoate
Chemical_Nomenclature 3,4,5-trihydroxybenzoic acid
Canonical SMILES C1=C(C=C(C(=C1O)O)O)C(=O)O
InChI InChI=1S/C7H6O5/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,8-10H,(H,11,12)
InChIKey LNTHITQWFMADLM-UHFFFAOYSA-N
Other name(s) Gallic acid ; 3,4,5-Trihydroxybenzoic acid ; Benzoic acid, 3,4,5-trihydroxy- ; Gallic acid, tech.
________________________________________________________________________________________________
MW|170.12
Formula|C7H6O5
CAS_number|149-91-7
PubChem|370
UniChem|LNTHITQWFMADLM-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Gallate ligand of proteins in family: Tannase_Bact
Stucture | 2 structures: 7K4O, 4J0H
Protein | lacpl-tanL

References:
Search PubMed for references concerning: Gallate
    Title: Gallic Acid as a Non-Selective Inhibitor of alpha/beta-Hydrolase Fold Enzymes Involved in the Inflammatory Process: The Two Sides of the Same Coin
    Toyama MH, Rogero A, de Moraes LLF, Fernandes GA, da Cruz Costa CR, Belchor MN, De Carli AM, de Oliveira MA
    Ref: Pharmaceutics, 14:, 2022 : PubMed

            

    Title: Crystal structure of tannase from lactobacillusplantarum
    Ren B, Wu M, Wang Q, Peng X, Wen H, McKinstry WJ, Chen Q
    Ref: Journal of Molecular Biology, 425:2737, 2013 : PubMed

            

    Title: Expression, purification, crystallization and preliminary X-ray analysis of tannase from Lactobacillus plantarum.
    Wu M, Peng X, Wen H, Wang Q, Chen Q, McKinstry WJ, Ren B
    Ref: Acta Crystallographica Sect F Struct Biol Cryst Commun, 69:456, 2013 : PubMed