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Inhibitor Report for: Glabridin

Inhibits tyrosinase. Has pleiotropic effects. Inhibitor of CES2A.High specificity over CES1A (>500-fold) and other serine hydrolases. Glabridin is cell permeable and low cytotoxicity. IC50 0.52 muM in cells


General
Type Natural, Flavonoid
Chemical_Nomenclature 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol
Canonical SMILES CC1(C=CC2=C(O1)C=CC3=C2OCC(C3)C4=C(C=C(C=C4)O)O)C
InChI InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChIKey LBQIJVLKGVZRIW-ZDUSSCGKSA-N
Other name(s) UNII-HOC5567T41 ; CHEBI:5369 ; HOC5567T41
________________________________________________________________________________________________
MW|324.37
Formula|C20H20O4
CAS_number|59870-68-7
PubChem|124052
UniChem|LBQIJVLKGVZRIW-ZDUSSCGKSA-N
IUPHAR|
Wikipedia|

Target
Families | Glabridin ligand of proteins in family: Carb_B_Chordata
Protein | human-CES2, mouse-Ces2a

References:
Search PubMed for references concerning: Glabridin
    Title: Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations
    Song SS, Sun CP, Zhou JJ, Chu L
    Ref: Int J Biol Macromol, 131:201, 2019 : PubMed