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Inhibitor Report for: HALSTS-1Q9

Compound close to HALSTS1 (Neklesa et al.) N-(3,5-dichloro-2-ethoxybenzyl)-2H-tetrazol-5-amine as a nanomolar HALoTag2 Stabilizer (HALTS1) that reduces the Hsp70:HaloTag2 interaction, thereby preventing HaloTag2 ubiquitination here di methyl instead of dichloro


General
Type HaloTag-ligand, Tetrazol
Chemical_Nomenclature N-[(2-ethoxy-3,5-dimethylphenyl)methyl]-2H-tetrazol-5-amine
Canonical SMILES CCOC1=C(C=C(C=C1CNC2=NNN=N2)C)C
InChI InChI=1S/C12H17N5O/c1-4-18-11-9(3)5-8(2)6-10(11)7-13-12-14-16-17-15-12/h5-6H,4,7H2,1-3H3,(H2,13,14,15,16,17)
InChIKey WHEQZFWVEMEFGH-UHFFFAOYSA-N
Other name(s) 1Q9
________________________________________________________________________________________________
MW|247.30
Formula|C12H17N5O
CAS_number|
PubChem|71464720
UniChem|WHEQZFWVEMEFGH-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | HALSTS-1Q9 ligand of proteins in family: Haloalkane_dehalogenase-HLD2
Stucture | 2 structures: 4KAJ, 4KAC
Protein | rhoso-halo1

References:
Search PubMed for references concerning: HALSTS-1Q9
    Title: A bidirectional system for the dynamic small molecule control of intracellular fusion proteins
    Neklesa TK, Noblin DJ, Kuzin AP, Lew S, Seetharaman J, Acton TB, Kornhaber GJ, Xiao R, Montelione GT and Crews CM <1 more author(s)>
    Ref: ACS Chemical Biology, 8:2293, 2013 : PubMed