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Inhibitor Report for: HDSF

PPT1 is insensitive to inactivation by PMSF or DFP, the enzyme is covalently modified and inactivated by hexadecylsulfonyl fluoride (HDSF). The active site do not accommodate an aromatic sulfonyl fluoride.



General
Type: Sulfur Compound
Chemical_Nomenclature: hexadecane-1-sulfonyl fluoride
Canonical SMILES: CCCCCCCCCCCCCCCCS(=O)(=O)F
InChI: InChI=1S/C16H33FO2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(17,18)19/h2-16H2,1H3
InChIKey: QIVFMUVBIHIZAM-UHFFFAOYSA-N
Other name(s): Hexadecylsulfonyl fluoride ; Hexadecanesulfonyl fluoride ; CHEMBL94809 ; CHEBI:43275
MW: 308.49
Formula: C16H33FO2S
CAS_number: 86855-26-7
PubChem: 3572
IUPHAR:
Wikipedia:

Target families
HDSF ligand of proteins in family: Palmitoyl-protein_thioesterase

Stucture of targets
1 structure:
1EXW: Palmitoyl Protein Thioesterase 1 Complexed With Hexadecylsulfonyl Fluoride

Protein target
Enzyme: bovin-ppt

References
Search PubMed for references concerning: HDSF
    Title: Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride
    Das AK, Bellizzi JJ, 3rd, Tandel S, Biehl E, Clardy J, Hofmann SL
    Ref: Journal of Biological Chemistry, 275:23847, 2000 : PubMed