Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Icopezil

Unii-RY1AR8DY6G CID 10318177 is a derivative of icopezil with a methyl group that could be labeled 11C to be used as a pet probe


General
Type Piperidine, Derivative of Donepezil
Chemical_Nomenclature 5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one
Canonical SMILES C1CN(CCC1CCC2=C3C=C4CC(=O)N=C4C=C3ON2)CC5=CC=CC=C5 C1CN(CCC1CCC2=NOC3=C2C=C4CC(=O)NC4=C3)CC5=CC=CC=C5
InChI InChI=1S/C23H25N3O2/c27-23-13-18-12-19-20(25-28-22(19)14-21(18)24-23)7-6-16-8-10-26(11-9-16)15-17-4-2-1-3-5-17/h1-5,12,14,16,25H,6-11,13,15H2 InChI=1S/C23H25N3O2/c27-23-13-18-12-19-20(25-28-22(19)14-21(18)24-23)7-6-16-8-10-26(11-9-16)15-17-4-2-1-3-5-17/h1-5,12,14,16H,6-11,13,15H2,(H,24,27)
InChIKey DNFGPFRQSJOKEZ-UHFFFAOYSA-N MTCMTKNMZCPKLX-UHFFFAOYSA-N
Other name(s) CP-118954 ; CP-118,954 ; CP 118,954 ; UNII-ERZ60E6B7C ; CHEMBL359570 ; CP 118954
________________________________________________________________________________________________
MW|375.46
Formula|C23H25N3O2
CAS_number|145508-78-7
PubChem|5490675, 172972
UniChem|DNFGPFRQSJOKEZ-UHFFFAOYSA-N, MTCMTKNMZCPKLX-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Icopezil ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: Icopezil

3 more
    Title: Synthesis and evaluation of 2-[18F]fluoro-CP-118,954 for the in vivo mapping of acetylcholinesterase
    Ryu EK, Choe YS, Park EY, Paik JY, Kim YR, Lee KH, Choi Y, Kim SE, Kim BT
    Ref: Nucl Med Biol, 32:185, 2005 : PubMed

            

    Title: Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease
    Liston DR, Nielsen JA, Villalobos A, Chapin D, Jones SB, Hubbard ST, Shalaby IA, Ramirez A, Nason D, White WF
    Ref: European Journal of Pharmacology, 486:9, 2004 : PubMed

            

    Title: 5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety
    Villalobos A, Butler TW, Chapin DS, Chen YL, DeMattos SB, Ives JL, Jones SB, Liston DR, Nagel AA and et al. <1 more author(s)>
    Ref: Journal of Medicinal Chemistry, 38:2802, 1995 : PubMed