Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: JW480

JW480 is a selective inhibitor of human-NCEH1 (KIAA1363, AADACL1) (IC50s = 20 nM in mouse brain membrane proteomes and 6-12 nM in human PC3 prostate cancer cell proteomes) It inhibits moderately also CES1 and CES2


General
Type Carbamate, Naphthalen
Chemical_Nomenclature (2-propan-2-ylphenyl) N-(2-naphthalen-2-ylethyl)carbamate
Canonical SMILES CC(C)C1=CC=CC=C1OC(=O)NCCC2=CC3=CC=CC=C3C=C2
InChI
InChIKey PCNJGBMWAZRVEA-UHFFFAOYSA-N
Other name(s) SCHEMBL4433152 ; JW 480 ; JW-480 ; ZINC71746265 ; AKOS024458096
________________________________________________________________________________________________
MW|333.42
Formula|C22H23NO2
CAS_number|1354359-53-7
PubChem|57330099
UniChem|PCNJGBMWAZRVEA-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | JW480 ligand of proteins in family: Arylacetamide_deacetylase
Protein | human-NCEH1

References:
Search PubMed for references concerning: JW480
    Title: A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis
    Chang JW, Nomura DK, Cravatt BF
    Ref: Chemical Biology, 18:476, 2011 : PubMed