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Inhibitor Report for: LEI-106

Dual DAGL alpha/ ABHD6 inhibitor. DAGL alpha Ki= 0.7 +/- 0.08 muM. ABHD6 Ki= 0.8 +/- 0.1 muM


General
Type Sulfur Compound, Phenoxyphenyl
Chemical_Nomenclature 2-[(2,2-dimethyl-3,4-dihydrochromen-6-yl)sulfonyl-[(4-phenoxyphenyl)methyl]amino]acetic acid
Canonical SMILES CC1(CCC2=C(O1)C=CC(=C2)S(=O)(=O)N(CC3=CC=C(C=C3)OC4=CC=CC=C4)CC(=O)O)C
InChI InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)
InChIKey FOEGBOXMDBPYEV-UHFFFAOYSA-N
Other name(s) CHEMBL3319620 ; BDBM50048620 ; ZINC299817132
________________________________________________________________________________________________
MW|481.6
Formula|C26H27NO6S
CAS_number|1620582-23-1
PubChem|102340761
UniChem|FOEGBOXMDBPYEV-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | LEI-106 ligand of proteins in family: Lipase_3, ABHD6-Lip
Protein | human-DAGLA, human-ABHD6

References:
Search PubMed for references concerning: LEI-106
    Title: Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase alpha and alpha/beta-Hydrolase Domain 6
    Janssen FJ, Deng H, Baggelaar MP, Allara M, van der Wel T, den Dulk H, Ligresti A, van Esbroeck AC, McGuire R and van der Stelt M <2 more author(s)>
    Ref: Journal of Medicinal Chemistry, 57:6610, 2014 : PubMed