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Inhibitor Report for: LIPG-inhib-Compound8i

human serum IC50, human-LIPG (endothelial) EL IC50 13 (nM), human-LIPC (hepatic) HL 5.4 (nM)


General
Type Cyanide, Benzothiazol, Sulfur Compound, Cyclopropyl
Chemical_Nomenclature 2-cyano-N-[2-(cyclopropylamino)-2-oxoethyl]-2-(6-phenyl-1,3-benzothiazol-2-yl)acetamide
Canonical SMILES C1CC1NC(=O)CNC(=O)C(C#N)C2=NC3=C(S2)C=C(C=C3)C4=CC=CC=C4
InChI InChI=1S/C21H18N4O2S/c22-11-16(20(27)23-12-19(26)24-15-7-8-15)21-25-17-9-6-14(10-18(17)28-21)13-4-2-1-3-5-13/h1-6,9-10,15-16H,7-8,12H2,(H,23,27)(H,24,26)
InChIKey SHNOGRNWVUNUKY-UHFFFAOYSA-N
Other name(s) SCHEMBL19709502
________________________________________________________________________________________________
MW|390.5
Formula|C21H18N4O2S
CAS_number|
PubChem|132227197
UniChem|SHNOGRNWVUNUKY-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | LIPG-inhib-Compound8i ligand of proteins in family: Lipoprotein_Lipase
Protein | human-LIPG

References:
Search PubMed for references concerning: LIPG-inhib-Compound8i
    Title: Benzothiazole-based compounds as potent endothelial lipase inhibitors
    Meng W, Adam LP, Behnia K, Zhao L, Yang R, Kopcho LM, Locke GA, Taylor DS, Yin X and Finlay H <1 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, :126673, 2019 : PubMed