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Inhibitor Report for: LP-922056

Thienopyrimidine orally active inhibitor of NOTUM potential drug for stimulating bone formation and treating osteoporosis IC50 1.1 +/- 0.4 nM


General
Type Pyrimidine, Sulfur Compound, Cyclopropyl
Chemical_Nomenclature 2-(6-chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)sulfanylacetic acid
Canonical SMILES C1CC1C2=C(SC3=C2N=CN=C3SCC(=O)O)Cl
InChI InChI=1S/C11H9ClN2O2S2/c12-10-7(5-1-2-5)8-9(18-10)11(14-4-13-8)17-3-6(15)16/h4-5H,1-3H2,(H,15,16)
InChIKey LJYRIWUQISYYHA-UHFFFAOYSA-N
Other name(s) CHEMBL3774760 ; SCHEMBL439279 ; BDBM50154397
________________________________________________________________________________________________
MW|300.77
Formula|C11H9ClN2O2S2
CAS_number|
PubChem|56932967
UniChem|LJYRIWUQISYYHA-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | LP-922056 ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 6T2K: Furano[2,3-d]prymidine amides as Notum inhibitors 2 (LP-922056)
Protein | human-NOTUM, mouse-notum

References:
Search PubMed for references concerning: LP-922056

3 more
    Title: Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors
    Atkinson BN, Steadman D, Mahy W, Zhao Y, Sipthorp J, Bayle ED, Svensson F, Papageorgiou G, Jeganathan F and Fish PV <4 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, :126751, 2019 : PubMed

            

    Title: An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent
    Willis NJ, Bayle ED, Papageorgiou G, Steadman D, Atkinson BN, Mahy W, Fish PV
    Ref: Beilstein J Org Chem, 15:2790, 2019 : PubMed

            

    Title: Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase
    Tarver JE, Jr., Pabba PK, Barbosa J, Han Q, Gardyan MW, Brommage R, Thompson AY, Schmidt JM, Wilson AG and Wilson AGE <3 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 26:1525, 2016 : PubMed