Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Lalistat-1

Apart from Lysosomal acid lipase human-LIPA, Lalistat-1 and -2 also inhibit major cytosolic lipid hydrolases responsible for lipid degradation in primary cells at neutral pH through off-target effects (ATGL not alpha/beta hydrolas; HSL hormone sensitive lipase); MGL Monoglyceride lipase). Lalistat also impairs Mycobacterium tuberculosis growth by targeting hydolases LipR Rv3084 Rv1984c Rv0183


General
Type Piperidine, Lipase inhibitor, Sulfur Compound, Thiadiazol
Chemical_Nomenclature (4-piperidin-1-yl-1,2,5-thiadiazol-3-yl) morpholine-4-carboxylate
Canonical SMILES C1CCN(CC1)C2=NSN=C2OC(=O)N3CCOCC3
InChI InChI=1S/C12H18N4O3S/c17-12(16-6-8-18-9-7-16)19-11-10(13-20-14-11)15-4-2-1-3-5-15/h1-9H2
InChIKey XAWUWPUYJUOUOF-UHFFFAOYSA-N
Other name(s) 4-(piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate ; CHEMBL1085463 ; SCHEMBL17078235 ; ZINC795230
________________________________________________________________________________________________
MW|298.36
Formula|C12H18N4O3S
CAS_number|501104-16-1
PubChem|651937
UniChem|XAWUWPUYJUOUOF-UHFFFAOYSA-N
IUPHAR|
Wikipedia|


References:
Search PubMed for references concerning: Lalistat-1

1 more
    Title: Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases
    Bradic I, Kuentzel KB, Honeder S, Grabner GF, Vujic N, Zimmermann R, Birner-Gruenberger R, Kratky D
    Ref: Mol Metab, :101510, 2022 : PubMed

            

    Title: Loss of Function of Lysosomal Acid Lipase (LAL) Profoundly Impacts Osteoblastogenesis and Increases Fracture Risk in Humans
    Helderman RC, Whitney DG, Duta-Mare M, Akhmetshina A, Vujic N, Jayapalan S, Nyman JS, Misra BB, Rosen CJ and Rendina-Ruedy E <2 more author(s)>
    Ref: Bone, :115946, 2021 : PubMed

            

    Title: Physiological difference in autophagic flux in macrophages from 2 mouse strains regulates cholesterol ester metabolism
    Robinet P, Ritchey B, Smith JD
    Ref: Arterioscler Thromb Vasc Biol, 33:903, 2013 : PubMed