IC50 0.53 microM human-DPP8 500 microM human-dpp4
Type : Acetanilide,Peptide,Indole,Organophosphate
Chemical_Nomenclature : N-[4-[(4-acetamidophenoxy)-[2-[(2S)-2,6-diaminohexanoyl]-1,3-dihydroisoindol-1-yl]phosphoryl]oxyphenyl]acetamide
Canonical SMILES : CC(=O)NC1=CC=C(C=C1)OP(=O)(C2C3=CC=CC=C3CN2C(=O)C(CCCCN)N)OC4=CC=C(C=C4)NC(=O)C
InChI : InChI=1S\/C30H36N5O6P\/c1-20(36)33-23-10-14-25(15-11-23)40-42(39,41-26-16-12-24(13-17-26)34-21(2)37)30-27-8-4-3-7-22(27)19-35(30)29(38)28(32)9-5-6-18-31\/h3-4,7-8,10-17,28,30H,5-6,9,18-19,31-32H2,1-2H3,(H,33,36)(H,34,37)\/t28-,30?\/m0\/s1
InChIKey : MKKBABAOGFLBRQ-MBCWZBCWSA-N
Other name(s) : CHEMBL440982,BDBM50225425,Compoound 2e,di-(4-acetamido)phenyl 2-((S)-2,6-diaminohexanoyl)isoindolin-1-ylphosphonate
MW : 593.6
Formula : C30H36N5O6P
CAS_number :
PubChem : 23655476
UniChem : MKKBABAOGFLBRQ-MBCWZBCWSA-N
IUPHAR :
Wikipedia :
Families : Lys-phospho-isoindoline ligand of proteins in family: DPP4N_Peptidase_S9
Stucture :
Protein : human-DPP8
Title : Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates - Van der Veken_2007_J.Med.Chem_50_5568 |
Author(s) : Van der Veken P , Soroka A , Brandt I , Chen YS , Maes MB , Lambeir AM , Chen X , Haemers A , Scharpe S , Augustyns K , De Meester I |
Ref : Journal of Medicinal Chemistry , 50 :5568 , 2007 |
Abstract : Van der Veken_2007_J.Med.Chem_50_5568 |
ESTHER : Van der Veken_2007_J.Med.Chem_50_5568 |
PubMedSearch : Van der Veken_2007_J.Med.Chem_50_5568 |
PubMedID: 17958345 |