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Inhibitor Report for: MAGL17b

Ki = 0.65 microM IC50=0.84 microM


General
Type Piperidine
Chemical_Nomenclature (4-chlorophenyl)-[1-(3-hydroxybenzoyl)piperidin-4-yl]methanone
Canonical SMILES C1CN(CCC1C(=O)C2=CC=C(C=C2)Cl)C(=O)C3=CC(=CC=C3)O
InChI InChI=1S/C19H18ClNO3/c20-16-6-4-13(5-7-16)18(23)14-8-10-21(11-9-14)19(24)15-2-1-3-17(22)12-15/h1-7,12,14,22H,8-11H2
InChIKey XSAQFVZJTOJQCI-UHFFFAOYSA-N
Other name(s) CHEMBL4282040 ; BDBM50470454 ; J3.612.244G ; 1-(3-Hydroxybenzoyl)-4-(4-chlorobenzoyl)piperidine
________________________________________________________________________________________________
MW|343.8
Formula|C19H18ClNO3
CAS_number|
PubChem|132941103
UniChem|XSAQFVZJTOJQCI-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | MAGL17b ligand of proteins in family: Monoglyceridelipase_lysophospholip
Protein | human-MGLL

References:
Search PubMed for references concerning: MAGL17b
    Title: MAGL inhibitor NanoMicellar formulation (MAGL-NanoMicellar) for the development of an antiglaucoma eye drop
    Chetoni P, Burgalassi S, Zucchetti E, Granchi C, Minutolo F, Tampucci S, Monti D
    Ref: Int J Pharm, :122078, 2022 : PubMed

            

    Title: Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors
    Granchi C, Rizzolio F, Palazzolo S, Carmignani S, Macchia M, Saccomanni G, Manera C, Martinelli A, Minutolo F, Tuccinardi T
    Ref: Journal of Medicinal Chemistry, 59:10299, 2016 : PubMed