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Inhibitor Report for: MK0626

General
Type Pyridine, Pyrrolidine, Triazol
Chemical_Nomenclature (2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide
Canonical SMILES CN(C)C(=O)C(C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)C(C(=O)N4CCC(C4)F)N
InChI InChI=1S/C22H25FN6O2/c1-27(2)21(30)19(20(24)22(31)28-10-9-17(23)12-28)15-5-3-14(4-6-15)16-7-8-18-25-13-26-29(18)11-16/h3-8,11,13,17,19-20H,9-10,12,24H2,1-2H3/t17-,19-,20-/m0/s1
InChIKey ZNHVIJAGMFQGMS-IHPCNDPISA-N
Other name(s) DB08504 ; MK-0626 ; CHEMBL537869 ; CHEMBL237337 ; 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM ; 2fjp ; SCHEMBL14591260 ; BDBM50221972
________________________________________________________________________________________________
MW|424.48
Formula|C22H25FN6O2
CAS_number|
PubChem|10320144, 11576569
UniChem|ZNHVIJAGMFQGMS-IHPCNDPISA-N
IUPHAR|
Wikipedia|

Target
Families | MK0626 ligand of proteins in family: DPP4N_Peptidase_S9
Stucture | 1 structure: 2FJP: Human dipeptidyl peptidase IV/CD26 in complex with an inhibitor
Protein | human-DPP4

References:
Search PubMed for references concerning: MK0626
    Title: (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]tr iazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    Edmondson SD, Mastracchio A, Mathvink RJ, He J, Harper B, Park YJ, Beconi M, Di Salvo J, Eiermann GJ and Weber AE <16 more author(s)>
    Ref: Journal of Medicinal Chemistry, 49:3614, 2006 : PubMed