Methyl-gamma-linolenyl-fluorophosphonate
Active Site-Specific Polyunsaturated Fatty Acyl Adduct
General
Type : Organophosphate
Chemical_Nomenclature : (6Z,9Z,12Z)-1-[fluoro(methoxy)phosphoryl]octadeca-6,9,12-triene
Canonical SMILES : CCCCCC=CCC=CCC=CCCCCCP(=O)(OC)F
InChI : InChI=1S\/C19H34FO2P\/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(20,21)22-2\/h7-8,10-11,13-14H,3-6,9,12,15-19H2,1-2H3\/b8-7-,11-10-,14-13-
InChIKey : PYIHGLSRUVHCML-JPFHKJGASA-N
Other name(s) : Methyl .gamma.-Linolenyl Fluorophosphonate,HMS3649A14,6Z,9Z,12Z-Octadecatrienylphosphonofluoridic acid, methyl ester
MW : 344.44
Formula : C19H34FO2P
CAS_number :
PubChem : 71684459
UniChem : PYIHGLSRUVHCML-JPFHKJGASA-N
IUPHAR :
Wikipedia :
Target
Families : Methyl-gamma-linolenyl-fluorophosphonate ligand of proteins in family: Thioesterase
Stucture : 3TJM Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct
Protein : human-FASN
References (1)
| Title : Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid - Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| Author(s) : Zhang W , Chakravarty B , Zheng F , Gu Z , Wu H , Mao J , Wakil SJ , Quiocho FA |
| Ref : Proc Natl Acad Sci U S A , 108 :15757 , 2011 |
| Abstract : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| ESTHER : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| PubMedSearch : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
| PubMedID: 21908709 |
| Gene_locus related to this paper: human-FASN |