N-10-Phenothiazine-3-(dimethylamino)phenyl-carbamate
(Compound 24 Darvesh et al. 2008) Ki BCHE 1.91 micro M (for comparison Donepezil 2.21 for BCHE and 0.024 for ACHE), Ka ACHE 19200 M-1min-1 (for comparison rivastigmine 1130 M-1min-1)
General
Type : Phenothiazine,Carbamate,Sulfur Compound
Chemical_Nomenclature : [3-(dimethylamino)phenyl] phenothiazine-10-carboxylate
Canonical SMILES : CN(C)C1=CC(=CC=C1)OC(=O)N2C3=CC=CC=C3SC4=CC=CC=C42
InChI : InChI=1S\/C21H18N2O2S\/c1-22(2)15-8-7-9-16(14-15)25-21(24)23-17-10-3-5-12-19(17)26-20-13-6-4-11-18(20)23\/h3-14H,1-2H3
InChIKey : UCJSIBVJIPKASB-UHFFFAOYSA-N
Other name(s) : CHEMBL481908,BDBM50292624,3-(dimethylamino)phenyl 10H-phenothiazine-10-carboxylate
MW : 362.4
Formula : C21H18N2O2S
CAS_number :
PubChem : 24905654
UniChem : UCJSIBVJIPKASB-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
phenyl-carbamate.gif)
Target
Families : N-10-Phenothiazine-3-(dimethylamino)phenyl-carbamate ligand of proteins in family: BCHE
Stucture :
Protein :
References (2)
| Title : Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems - Darvesh_2013_Bioorg.Med.Chem.Lett_23_3822 |
| Author(s) : Darvesh S , Macdonald IR , Martin E |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :3822 , 2013 |
| Abstract : Darvesh_2013_Bioorg.Med.Chem.Lett_23_3822 |
| ESTHER : Darvesh_2013_Bioorg.Med.Chem.Lett_23_3822 |
| PubMedSearch : Darvesh_2013_Bioorg.Med.Chem.Lett_23_3822 |
| PubMedID: 23707254 |
| Title : Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase - Darvesh_2008_J.Med.Chem_51_4200 |
| Author(s) : Darvesh S , Darvesh KV , McDonald RS , Mataija D , Walsh R , Mothana S , Lockridge O , Martin E |
| Ref : Journal of Medicinal Chemistry , 51 :4200 , 2008 |
| Abstract : Darvesh_2008_J.Med.Chem_51_4200 |
| ESTHER : Darvesh_2008_J.Med.Chem_51_4200 |
| PubMedSearch : Darvesh_2008_J.Med.Chem_51_4200 |
| PubMedID: 18570368 |