N-p-phenylazophenylcarbamylcholine
Open-channel blocker (local anesthetic) cis conformation most active
General
Type : Photoswitch,Trimethylammonium,Not A\/B H target,Nicotinic agonist
Chemical_Nomenclature : trimethyl-[2-[(4-phenyldiazenylphenyl)carbamoyloxy]ethyl]azanium\;iodide
Canonical SMILES : C[N+](C)(C)CCOC(=O)NC1=CC=C(C=C1)N=NC2=CC=CC=C2.[I-]
InChI : InChI=1S\/C18H22N4O2.HI\/c1-22(2,3)13-14-24-18(23)19-15-9-11-17(12-10-15)21-20-16-7-5-4-6-8-16\;\/h4-12H,13-14H2,1-3H3\;1H
InChIKey : CLDSCTOEEKXOSU-UHFFFAOYSA-N || YSXJRIYPAVANCT-UHFFFAOYSA-O
Other name(s) : PAPC,PAPF,PADPCC,EW 1,EW-1,N-p-Phenylazophenylcarbamylcholine iodide,N,N,N-Trimethyl-2-((((4-(phenylazo)phenyl)amino)carbon yl)oxy)ethanaminium, iodide
MW : 454.3
Formula : C18H23IN4O2
CAS_number : 29739-76-2
UniChem : CLDSCTOEEKXOSU-UHFFFAOYSA-N || YSXJRIYPAVANCT-UHFFFAOYSA-O
IUPHAR :
Wikipedia :
Target
Families :
Stucture :
Protein :
References (5)
| Title : Physiological and pharmacological manipulations with light flashes - |
| Author(s) : Lester HA , Nerbonne JM |
| Ref : Annu Rev Biophys Bioeng , 11 :151 , 1982 |
| PubMedID: 7049061 |
| Title : Electrophysiological experiments with photoisomerizable cholinergic compounds: review and progress report - |
| Author(s) : Lester HA , Nass MM , Krouse ME , Nerbonne JM , Wassermann NH , Erlanger BF |
| Ref : Annals of the New York Academy of Sciences , 346 :475 , 1980 |
| PubMedID: 6247953 |
| Title : Photoregulation of biological activity by photochromic reagents. Inactivators of acetylcholinesterase - Bieth_1973_Biochemistry_12_3023 |
| Author(s) : Bieth J , Vratsanos SM , Wassermann NH , Cooper AG , Erlanger BF |
| Ref : Biochemistry , 12 :3023 , 1973 |
| Abstract : Bieth_1973_Biochemistry_12_3023 |
| ESTHER : Bieth_1973_Biochemistry_12_3023 |
| PubMedSearch : Bieth_1973_Biochemistry_12_3023 |
| PubMedID: 4738308 |
| Title : Photoregulation of biological activity by photocromic reagents. II. Inhibitors of acetylcholinesterase - Bieth_1969_Proc.Natl.Acad.Sci.U.S.A_64_1103 |
| Author(s) : Bieth J , Vratsanos SM , Wassermann N , Erlanger BF |
| Ref : Proc Natl Acad Sci U S A , 64 :1103 , 1969 |
| Abstract : Bieth_1969_Proc.Natl.Acad.Sci.U.S.A_64_1103 |
| ESTHER : Bieth_1969_Proc.Natl.Acad.Sci.U.S.A_64_1103 |
| PubMedSearch : Bieth_1969_Proc.Natl.Acad.Sci.U.S.A_64_1103 |
| PubMedID: 5264140 |
| Title : Photoregulation of an enzymic process by means of a light-sensitive ligand - Kaufman_1968_Science_162_1487 |
| Author(s) : Kaufman H , Vratsanos SM , Erlanger BF |
| Ref : Science , 162 :1487 , 1968 |
| Abstract : Kaufman_1968_Science_162_1487 |
| ESTHER : Kaufman_1968_Science_162_1487 |
| PubMedSearch : Kaufman_1968_Science_162_1487 |
| PubMedID: 5700068 |