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Inhibitor Report for: NMDA-BCHE-C-2h

Memantine Tetrahydrocarbazol conjugate: inhibit BChE (without noticeable suppression of the AChE activity) and block the ifenprodil-binding site of NMDA receptors containing NR2B subunits


General
Type Multitarget, NMDA-Ligand, Carbazol, Adamantyl
Chemical_Nomenclature
Canonical SMILES CC13CC2CC(C1)(CC(C2)(C3)NCC(C[N]5C4=C(CCCC4)C6=C5C=CC(=C6)F)O)C
InChI InChI=1S/C27H37FN2O/c1-25-10-18-11-26(2,15-25)17-27(12-18,16-25)29-13-20(31)14-30-23-6-4-3-5-21(23)22-9-19(28)7-8-24(22)30/h7-9,18,20,29,31H,3-6,10-17H2,1-2H3
InChIKey JSYAQHFJGTVUOE-UHFFFAOYSA-N
Other name(s)
________________________________________________________________________________________________
MW|424.59
Formula|C27H37FN2O
CAS_number|
PubChem|
UniChem|JSYAQHFJGTVUOE-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | NMDA-BCHE-C-2h ligand of proteins in family: BCHE

References:
Search PubMed for references concerning: NMDA-BCHE-C-2h
    Title: Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
    Bachurin SO, Shevtsova EF, Makhaeva GF, Grigoriev VV, Boltneva NP, Kovaleva NV, Lushchekina SV, Shevtsov PN, Neganova ME and Aliev G <8 more author(s)>
    Ref: Sci Rep, 7:45627, 2017 : PubMed