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Inhibitor Report for: PIMP

sarin analogue. Less toxic but giving the same adduct


General
Type Organophosphate, Surrogate OP, Nerve Agent G-series, Derivative of Sarin, Isoindole
Chemical_Nomenclature 2-[methyl(propan-2-yloxy)phosphoryl]oxyisoindole-1,3-dione
Canonical SMILES CC(C)OP(=O)(C)ON1C(=O)C2=CC=CC=C2C1=O
InChI InChI=1S/C12H14NO5P/c1-8(2)17-19(3,16)18-13-11(14)9-6-4-5-7-10(9)12(13)15/h4-8H,1-3H3
InChIKey KVQCPBJKHFOQSK-UHFFFAOYSA-N
Other name(s) Phthalimidyl isopropyl methylphosphonate
________________________________________________________________________________________________
MW|283.22
Formula|C12H14NO5P
CAS_number|
PubChem|87411366
UniChem|KVQCPBJKHFOQSK-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | PIMP ligand of proteins in family: ACHE

References:
Search PubMed for references concerning: PIMP

1 more
    Title: Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase
    Coban A, Carr RL, Chambers HW, Willeford KO, Chambers JE
    Ref: Toxicol Lett, 248:39, 2016 : PubMed

            

    Title: Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates
    Chambers JE, Chambers HW, Meek EC, Pringle RB
    Ref: Chemico-Biological Interactions, 203:135, 2013 : PubMed

            

    Title: Synthesis and in vitro and in vivo inhibition potencies of highly relevant nerve agent surrogates
    Meek EC, Chambers HW, Coban A, Funck KE, Pringle RB, Ross MK, Chambers JE
    Ref: Toxicol Sci, 126:525, 2012 : PubMed