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Inhibitor Report for: PMSF

An enzyme inhibitor that inactivates cholinesterases, esterases, lipases, IRC-50 arvin, subtilisin, the fatty acid synthetase complex and many other serine hydrolases unrelated to alpha/beta hydrolases. Do not inhibit PlaB


General
Type Sulfur Compound, Sulfonyl
Chemical_Nomenclature Phenylmethylsulfonyl fluoride
Canonical SMILES C1=CC=C(C=C1)CS(=O)(=O)F
InChI InChI=1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChIKey YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Other name(s) Phenylmethanesulfonyl fluoride ; Benzenemethanesulfonyl fluoride ; alpha-Toluenesulfonyl fluoride
________________________________________________________________________________________________
MW|174.2
Formula|C7H7FO2S
CAS_number|329-98-6
PubChem|4784
UniChem|YBYRMVIVWMBXKQ-UHFFFAOYSA-N
IUPHAR|
Wikipedia|PMSF

Target
Families | PMSF ligand of proteins in family: BCHE, ACHE, LYsophospholipase_carboxylesterase, GTSAGmotif, Polyesterase-lipase-cutinase, Hormone-sensitive_lipase_like, RsbQ-like, CarbLipBact_2, Thioesterase, Dienelactone_hydrolase, Acetyl-esterase_deacetylase, Peptidase_S37, Peptidase_S15, Lactobacillus_peptidase, Cocaine_esterase, BioH, Bacterial_lip_FamI.5, Bacterial_lip_FamI.1, PolyAspartate-hydrolase, Cutinase, emeni-q5avy9, ABHD10, S9N_PREPL_Peptidase_S9, PE-PPE, Kynurenine-formamidase, DPP4N_Peptidase_S9, Pectinacetylesterase-Notum, Monoglyceridelipase_lysophospholip, CarbLipBact_1
Stucture | 25 structures (e.g. : 1AUR, 7V8X, 7Q4H... more)
Protein | human-ABHD10, human-PREPL, myctu-Rv1430, psefl-cxest, 9bact-E40, thefu-q6a0i4, ecoli-Aes, orysj-Q10QA5, bac25-mglp, 9bact-Q0GMU2, bacsu-FENB, psepu-clcd1, thema-TM0077, bacsu-yvfQ, ecoli-bioh, drome-CG9542, human-FAP, tubmm-TmEst2, human-NOTUM, cutac-e6dae5, 9gamm-urc15994, 9baci-EstD9

References:
Search PubMed for references concerning: PMSF

6 more
    Title: Phenylmethylsulfonyl fluoride inhibitory effects on acetylcholinesterase of brain and muscle
    Skau KA, Shipley MT
    Ref: Neuropharmacology, 38:691, 1999 : PubMed

            

    Title: Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers
    James GT
    Ref: Analytical Biochemistry, 86:574, 1978 : PubMed

            

    Title: The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, chymotyrpsin and trypsin
    Turini P, Kurooka S, Steer M, Corbascio AN, Singer TP
    Ref: Journal of Pharmacology & Experimental Therapeutics, 167:98, 1969 : PubMed