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Inhibitor Report for: PTUPB

COX-2/sEH dual inhibition. dual cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH) inhibitor


General
Type Multitarget, Trifluoro, Urea derivative, Sulfur Compound, Sulfonamide, Pyrazole
Chemical_Nomenclature 1-[3-[5-phenyl-1-(4-sulfamoylphenyl)pyrazol-3-yl]propyl]-3-[4-(trifluoromethyl)phenyl]urea
Canonical SMILES C1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)CCCNC(=O)NC4=CC=C(C=C4)C(F)(F)F
InChI InChI=1S/C26H24F3N5O3S/c27-26(28,29)19-8-10-20(11-9-19)32-25(35)31-16-4-7-21-17-24(18-5-2-1-3-6-18)34(33-21)22-12-14-23(15-13-22)38(30,36)37/h1-3,5-6,8-15,17H,4,7,16H2,(H2,30,36,37)(H2,31,32,35)
InChIKey CSEPEVFNTFMBAE-UHFFFAOYSA-N
Other name(s) CHEMBL1766287 ; SCHEMBL9938619
________________________________________________________________________________________________
MW|543.6
Formula|C26H24F3N5O3S
CAS_number|1287761-01-6
PubChem|52951990
UniChem|CSEPEVFNTFMBAE-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | PTUPB ligand of proteins in family: Epoxide_hydrolase
Protein | human-EPHX2

References:
Search PubMed for references concerning: PTUPB

9 more
    Title: COX-2/sEH Dual Inhibitor PTUPB Attenuates Epithelial-Mesenchymal Transformation of Alveolar Epithelial Cells via Nrf2-Mediated Inhibition of TGF-beta1/Smad Signaling
    Zhang CY, Guan XX, Song ZH, Jiang HL, Liu YB, Chen P, Duan JX, Zhou Y
    Ref: Oxid Med Cell Longev, 2022:5759626, 2022 : PubMed

            

    Title: Dual sEH/COX-2 Inhibition Using PTUPB-A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity
    Jankiewicz WK, Barnett SD, Stavniichuk A, Hwang SH, Hammock BD, Belayet JB, Khan AH, Imig JD
    Ref: Front Pharmacol, 12:744776, 2021 : PubMed

            

    Title: Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor
    Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D and Panigrahy D <3 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 116:1698, 2019 : PubMed