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Inhibitor Report for: Palmitoleic-acid

Palmitoleic acid, or 9-hexadecenoic acid, is an unsaturated fatty acid that is a common constituent of the glycerides of human adipose tissue. Present in all tissues, generally found in higher concentrations in the liver. Macadamia oil (Macadamia integrifolia) and Sea Buckthorn oil (Hippophae rhamnoides) are botanical sources of palmitoleic acid, containing 22 and 40% respectively . Palmitoleic acid is found to be associated with isovaleric acidemia, which is an inborn error of metabolism . Product of hydrolysis of Wnt acylated protein IC50 471 microM


General
Type Natural, Fatty acid
Chemical_Nomenclature (Z)-hexadec-9-enoic acid
Canonical SMILES CCCCCCC=CCCCCCCCC(=O)O
InChI InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/b8-7-
InChIKey SECPZKHBENQXJG-FPLPWBNLSA-N
Other name(s) Palmitoleic acid ; Cis-9-Hexadecenoic acid ; (Z)-Hexadec-9-enoic acid ; 9-cis-Hexadecenoic acid ; Zoomaric acid ; PAM
________________________________________________________________________________________________
MW|254.41
Formula|C16H30O2
CAS_number|373-49-9
PubChem|445638
UniChem|SECPZKHBENQXJG-FPLPWBNLSA-N
IUPHAR|
Wikipedia|Palmitoleic_acid

Target
Families | Palmitoleic-acid ligand of proteins in family: Pectinacetylesterase-Notum
Stucture | 1 structure: 4UZQ: Structure of the wnt deacetylase notum in complex with O-Palmitoleoyl serine- Crystal form IX - 1.5A
Protein | human-NOTUM

References:
Search PubMed for references concerning: Palmitoleic-acid
    Title: Notum deacylates Wnt proteins to suppress signalling activity
    Kakugawa S, Langton PF, Zebisch M, Howell SA, Chang TH, Liu Y, Feizi T, Bineva G, O'Reilly N and Vincent JP <2 more author(s)>
    Ref: Nature, 519:187, 2015 : PubMed