Polypropyleneglycol-fragment-C8
eight-carbon fragment of polypropylene glycol (PPG, C8O5), an additive in the crystallization buffer. The fragment is located in the fatty acyl chain-binding site. In one chain the fragment modeled is longer QVHMSMOUDQXMRS-WISYIIOYSA-N CID 77620522
General
Type : Polymer
Chemical_Nomenclature : (2R)-2-[(2R)-2-methoxypropoxy]propan-1-ol
Canonical SMILES : CC(CO)OCC(C)OC
InChI : InChI=1S\/C7H16O3\/c1-6(4-8)10-5-7(2)9-3\/h6-8H,4-5H2,1-3H3\/t6-,7-\/m1\/s1
InChIKey : CUDYYMUUJHLCGZ-RNFRBKRXSA-N
Other name(s) : 2Q5,(2R)-2-[(2R)-2-Methoxypropoxy]propan-1-ol
MW : 148.20
Formula : C7H16O3
CAS_number :
PubChem : 86308622
UniChem : CUDYYMUUJHLCGZ-RNFRBKRXSA-N
IUPHAR :
Wikipedia :
Target
Families : Polypropyleneglycol-fragment-C8 ligand of proteins in family: Thioesterase
Stucture : 5V3W Crystal Structure of the Apo form of Thioesterase domain of Mtb Pks13
Protein : myctu-PKS13
References (1)
| Title : Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 - Aggarwal_2017_Cell_170_249 |
| Author(s) : Aggarwal A , Parai MK , Shetty N , Wallis D , Woolhiser L , Hastings C , Dutta NK , Galaviz S , Dhakal RC , Shrestha R , Wakabayashi S , Walpole C , Matthews D , Floyd D , Scullion P , Riley J , Epemolu O , Norval S , Snavely T , Robertson GT , Rubin EJ , Ioerger TR , Sirgel FA , van der Merwe R , van Helden PD , Keller P , Bottger EC , Karakousis PC , Lenaerts AJ , Sacchettini JC |
| Ref : Cell , 170 :249 , 2017 |
| Abstract : Aggarwal_2017_Cell_170_249 |
| ESTHER : Aggarwal_2017_Cell_170_249 |
| PubMedSearch : Aggarwal_2017_Cell_170_249 |
| PubMedID: 28669536 |
| Gene_locus related to this paper: myctu-PKS13 |