King et al. found two naturally occurring terpendoids, pristimerin and euphol. Pristimerin (IC50 = 93 +/- 8 nM)
Type : Terpenoid,Natural
Chemical_Nomenclature : methyl (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylate
Canonical SMILES : CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)OC)C)C)C)C)O
InChI : InChI=1S\/C30H40O4\/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5\/h8-9,16,23,32H,10-15,17H2,1-7H3\/t23-,26-,27-,28+,29-,30+\/m1\/s1
InChIKey : JFACETXYABVHFD-WXPPGMDDSA-N
Other name(s) : Celastrol-methylether,GNF-PF-476,CHEBI:8416,Pristimerine
MW : 464.63
Formula : C30H40O4
CAS_number : 1258-84-0
PubChem : 159516
UniChem : JFACETXYABVHFD-WXPPGMDDSA-N
IUPHAR :
Wikipedia :
Families : Pristimerin ligand of proteins in family: Monoglyceridelipase_lysophospholip
Stucture :
Protein : human-MGLL
Title : Monoglyceride lipase: Structure and inhibitors - Scalvini_2016_Chem.Phys.Lipids_197_13 |
Author(s) : Scalvini L , Piomelli D , Mor M |
Ref : Chemistry & Physic of Lipids , 197 :13 , 2016 |
Abstract : Scalvini_2016_Chem.Phys.Lipids_197_13 |
ESTHER : Scalvini_2016_Chem.Phys.Lipids_197_13 |
PubMedSearch : Scalvini_2016_Chem.Phys.Lipids_197_13 |
PubMedID: 26216043 |
Title : Discovery of potent and reversible monoacylglycerol lipase inhibitors - King_2009_Chem.Biol_16_1045 |
Author(s) : King AR , Dotsey EY , Lodola A , Jung KM , Ghomian A , Qiu Y , Fu J , Mor M , Piomelli D |
Ref : Chemical Biology , 16 :1045 , 2009 |
Abstract : King_2009_Chem.Biol_16_1045 |
ESTHER : King_2009_Chem.Biol_16_1045 |
PubMedSearch : King_2009_Chem.Biol_16_1045 |
PubMedID: 19875078 |