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Inhibitor Report for: Prochlorperazine

Prochlorperazine and (trifluoperazine) stimulated the rate of acetylthiocholine (ATCh) hydrolysis by AChE (Katz et al. 2018). Prochlorperazine is a synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis


General
Type Phenothiazine, Sulfur Compound, Not A/B H target
Chemical_Nomenclature 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
Canonical SMILES CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
InChI InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3
InChIKey WIKYUJGCLQQFNW-UHFFFAOYSA-N
Other name(s) Prochlorperazin ; Prochlorpromazine ; Chlormeprazine
________________________________________________________________________________________________
MW|373.9
Formula|C20H24ClN3S
CAS_number|58-38-8
PubChem|4917
UniChem|WIKYUJGCLQQFNW-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: Prochlorperazine

3 more
    Title: Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review
    Otreba M, Kosmider L, Rzepecka-Stojko A
    Ref: European Journal of Pharmacology, 887:173553, 2020 : PubMed

            

    Title: New therapeutic approaches and novel alternatives for organophosphate toxicity
    Katz FS, Pecic S, Schneider L, Zhu Z, Hastings A, Luzac M, MacDonald J, Landry DW, Stojanovic MN
    Ref: Toxicol Lett, 291:1, 2018 : PubMed

            

    Title: Inhibition of butyrylcholinesterase by phenothiazine derivatives
    Debord J, Merle L, Bollinger JC, Dantoine T
    Ref: J Enzyme Inhib Med Chem, 17:197, 2002 : PubMed