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R-Pro-(decarboxy-Pro)-X97

General

Type : Pyrrolidine,Imidazole

Chemical_Nomenclature : 3-[4-oxo-4-[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]butyl]-5,5-diphenylimidazolidine-2,4-dione

Canonical SMILES : C1CCN(C1)C(=O)C2CCCN2C(=O)CCCN3C(=O)C(NC3=O)(C4=CC=CC=C4)C5=CC=CC=C5

InChI : InChI=1S\/C28H32N4O4\/c33-24(31-19-9-15-23(31)25(34)30-17-7-8-18-30)16-10-20-32-26(35)28(29-27(32)36,21-11-3-1-4-12-21)22-13-5-2-6-14-22\/h1-6,11-14,23H,7-10,15-20H2,(H,29,36)\/t23-\/m0\/s1

InChIKey : PHYVMRFCTLZIHY-QHCPKHFHSA-N

Other name(s) : CHEMBL516159,3-{4-Oxo-4-[(2s)-2-(Pyrrolidin-1-Ylcarbonyl)pyrrolidin-1-Yl]butyl}-5,5-Diphenylimidazolidine-2,4-Dione,3eq9,BDBM50275012,3-{4-Oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl}-5,5-diphenylimidazolidine-2,4-dione,X97

MW : 488.58

Formula : C28H32N4O4

CAS_number :

PubChem : 25155838

UniChem : PHYVMRFCTLZIHY-QHCPKHFHSA-N

IUPHAR :

Wikipedia :

Target

Families : R-Pro-(decarboxy-Pro)-X97 ligand of proteins in family: S9N_PPCE_Peptidase_S9

Stucture : 3EQ9 Prolyl oligopeptidase complexed with R-Pro-(decarboxy-Pro)-Type inhibitors 3

Protein : pig-ppce

References (1)

Title : Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules - Kanai_2008_J.Med.Chem_51_7514
Author(s) : Kannai K , Aranyi P , Bocskei Z , Ferenczy G , Harmat V , Simon K , Batori S , Naray-Szabo G , Hermecz I
Ref : Journal of Medicinal Chemistry , 51 :7514 , 2008
Abstract : Kanai_2008_J.Med.Chem_51_7514
ESTHER : Kanai_2008_J.Med.Chem_51_7514
PubMedSearch : Kanai_2008_J.Med.Chem_51_7514
PubMedID: 19006380
Gene_locus related to this paper: pig-q6q2c2